Efficacy of chloroquine and hydroxychloroquine for the treatment of hospitalized COVID-19 patients: a meta-analysis

被引：20

作者：

Deng, Jiawen ^{[1
]}

Zhou, Fangwen ^{[1
]}

Heybati, Kiyan ^{[1
,2
]}

Ali, Saif ^{[1
]}

Zuo, Qi Kang ^{[3
,4
]}

Hou, Wenteng ^{[1
]}

Dhivagaran, Thanansayan ^{[1
,5
]}

Ramaraju, Harikrishnaa Ba ^{[1
]}

Chang, Oswin ^{[1
]}

Wong, Chi Yi ^{[1
]}

Silver, Zachary ^{[6
]}

机构：

[1] McMaster Univ, Fac Hlth Sci, 1280 Main St W, Hamilton, ON L8S 4L8, Canada

[2] Mayo Clin, Alix Sch Med, 200 1st St SW, Rochester, MN 55905 USA

[3] Rutgers New Jersey Med Sch, Dept Anesthesiol, 185 S Orange Ave, Newark, NJ 07103 USA

[4] McGill Univ, Fac Sci, 845 Sherbrooke St W, Montreal, PQ H3A 0G5, Canada

[5] McMaster Univ, Integrated Biomed Engn & Hlth Sci Program iBioMed, 1280 Main St W, Hamilton, ON L8S 4L8, Canada

[6] Carleton Univ, Fac Sci, 1125 Colonel By Dr, Ottawa, ON K1S 5B6, Canada

来源：

FUTURE VIROLOGY | 2022年 / 17卷 / 02期

关键词：

azithromycin; chloroquine; COVID-19; hydroxychloroquine; length of stay; mechanical ventilation; mortality; QT prolongations; SARS-CoV-2; RESPIRATORY SYNDROME CORONAVIRUS; IN-VITRO; PUBLICATION BIAS; INFECTION; VIRUS; AZITHROMYCIN; PROLONGATION; REPLICATION; COMBINATION; INHIBITION;

D O I：

10.2217/fvl-2021-0119

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Aims: To evaluate the efficacy and safety of hydroxychloroquine/chloroquine, with or without azithromycin, in treating hospitalized COVID-19 patients. Materials & methods: Data from randomized and observational studies were included in a random-effects meta-analysis. Primary outcomes included time to negative conversion of SARS-CoV-2 tests, length of stay, mortality, incidence of mechanical ventilation, time to normalization of body temperature, incidence of adverse events and incidence of QT prolongations. Results: Fifty-one studies (n = 61,221) were included. Hydroxychloroquine/chloroquine showed no efficacy in all primary efficacy outcomes, but was associated with increased odds of QT prolongations. Conclusion: Due to a lack of efficacy and increased odds of cardiac adverse events, hydroxychloroquine/chloroquine should not be used for treating hospitalized COVID-19 patients.

引用

页码：95 / 118

页数：24

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