Molecular Thermodynamic Modeling and Design of Microencapsulation Systems for Drug Delivery

被引：7

作者：

Abildskov, Jens ^{[1
]}

O'Connell, John P. ^{[2
]}

机构：

[1] Tech Univ Denmark, Comp Aided Proc Engn Ctr, Dept Chem & Biochem Engn, DK-2800 Lyngby, Denmark

[2] Univ Virginia, Dept Chem Engn, Charlottesville, VA 22904 USA

来源：

JOURNAL OF CHEMICAL AND ENGINEERING DATA | 2011年 / 56卷 / 04期

关键词：

UNIFAC GROUP-CONTRIBUTION; VAPOR-LIQUID-EQUILIBRIA; MEDIUM-SIZED CHEMICALS; SOLVENT ACTIVITIES; POLYMER-SOLUTIONS; MIXED-SOLVENTS; PREDICTION; SOLUBILITY; MIXTURES; PARACETAMOL;

D O I：

10.1021/je1011218

中图分类号：

O414.1 [热力学];

学科分类号：

摘要：

A systematic design strategy is given for computer-aided design of microparticle drug-delivery systems produced by solvent evaporation. In particular, design of solvents, polymer material, and external phase composition are considered for the case when the active ingredient is known. The procedure is based on fundamental thermodynamic relations and group contributions to properties of pure species (solvent, active ingredient and polymer) and their mixtures. The method is intended for pharmaceuticals with complex molecular structures, for which limited experimental information is known. Case studies of solvent design are given.

引用

页码：1229 / 1237

页数：9

共 40 条

[1] Thermodynamic method for obtaining the solubilities of complex medium-sized chemicals in pure and mixed solvents
Abildskov, J
O'Connell, JP
[J]. FLUID PHASE EQUILIBRIA, 2005, 228 : 395 - 400
[2] Chemical product design - A new challenge of applied thermodynamics
Abildskov, J
Kontogeorgis, GM
[J]. CHEMICAL ENGINEERING RESEARCH & DESIGN, 2004, 82 (A11) : 1505 - 1510
[3] Prediction of solubilities of complex medium-sized chemicals. II. Solutes in mixed solvents
Abildskov, J
O'Connell, JP
[J]. MOLECULAR SIMULATION, 2004, 30 (06) : 367 - 378
[4] Predicting the solubilities of complex chemicals I. Solutes in different solvents
Abildskov, J
O'Connell, JP
[J]. INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 2003, 42 (22) : 5622 - 5634
[5] STATISTICAL THERMODYNAMICS OF LIQUID-MIXTURES - NEW EXPRESSION FOR EXCESS GIBBS ENERGY OF PARTLY OR COMPLETELY MISCIBLE SYSTEMS
ABRAMS, DS
PRAUSNITZ, JM
[J]. AICHE JOURNAL, 1975, 21 (01) : 116 - 128
[6] SWELLING EQUILIBRIA FOR ACRYLAMIDE-BASED POLYAMPHOLYTE HYDROGELS
BAKER, JP
STEPHENS, DR
BLANCH, HW
PRAUSNITZ, JM
[J]. MACROMOLECULES, 1992, 25 (07) : 1955 - 1958
[7] UNIFAC parameters for four new groups
Balslev, K
Abildskov, J
[J]. INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 2002, 41 (08) : 2047 - 2057
[8] The expanded Hansen approach to solubility parameters. Paracetamol and citric acid in individual solvents
Barra, J
Lescure, F
Doelker, E
Bustamante, P
[J]. JOURNAL OF PHARMACY AND PHARMACOLOGY, 1997, 49 (07) : 644 - 651
[9] Bustamante P., 1995, Pharm. Pharmacol. Commun, V1, P505, DOI DOI 10.1111/J.2042-7158.1995.TB00366.X
[10] ESTIMATION OF THE ACENTRIC FACTOR AND THE LIQUID MOLAR VOLUME AT 298-K USING A NEW GROUP-CONTRIBUTION METHOD
CONSTANTINOU, L
GANI, R
OCONNELL, JP
[J]. FLUID PHASE EQUILIBRIA, 1995, 103 (01) : 11 - 22

← 1 2 3 4 →