Endothelial-perivascular cell signaling in vascular development:: lessons from knockout mice

被引：77

作者：

Lindahl, P ^{[1
]}

Hellström, M ^{[1
]}

Kalén, M ^{[1
]}

Betsholtz, C ^{[1
]}

机构：

[1] Univ Gothenburg, Dept Med Biochem, SE-40530 Gothenburg, Sweden

来源：

CURRENT OPINION IN LIPIDOLOGY | 1998年 / 9卷 / 05期

关键词：

D O I：

10.1097/00041433-199810000-00004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The importance of perivascular-endothelial cell interactions during blood vessel development is discussed in the light of recent findings in platelet-derived growth factor-B, platelet-derived growth factor receptor-beta, angiopoietin-1 and tie-2 knockout mice, which all show deficient development of perivascular cells. The initial formation of networks of endothelial tubes (vasculogenesis) does not seem to depend on the perivascular cells but subsequent vessel remodeling relies on mesenchymal-endothelial short-range signaling. Based on findings in platelet-derived growth factor and platelet-derived growth factor receptor knockout mice, a general model for the role of platelet-derived growth factors in smooth muscle development is proposed. Curr Opin Lipidol 9:407-411. (C) 1998 Lippincott Williams & Wilkins

引用

页码：407 / 411

页数：5

共 23 条

[1]

Benjamin LE, 1998, DEVELOPMENT, V125, P1591

[2] Platelet-derived growth factor: A key regulator of connective tissue cells in embryogenesis and pathogenesis [J].

Betsholtz, C ;

Raines, EW .

KIDNEY INTERNATIONAL, 1997, 51 (05) :1361-1369

[3] PDGF-A signaling is a critical event in lung alveolar myofibroblast development and alveogenesis [J].

Bostrom, H ;

Willetts, K ;

Pekny, M ;

Leveen, P ;

Lindahl, P ;

Hedstrand, H ;

Pekna, M ;

Hellstrom, M ;

GebreMedhin, S ;

Schalling, M ;

Nilsson, M ;

Kurland, S ;

Tornell, J ;

Heath, JK ;

Betsholtz, C .

CELL, 1996, 85 (06) :863-873

[4]

CALVER AR, 1998, IN PRESS NEURON

[5] Role of tissue factor in embryonic blood vessel development [J].

Carmeliet, P ;

Mackman, N ;

Moons, L ;

Luther, T ;

Gressens, P ;

VanVlaenderen, I ;

Demunck, H ;

Kasper, M ;

Breier, G ;

Evrard, P ;

Muller, M ;

Risau, W ;

Edgington, T ;

Collen, D .

NATURE, 1996, 383 (6595) :73-75

[6] Chimaeric analysis reveals role of Pdgf receptors in all muscle lineages [J].

Crosby, JR ;

Seifert, RA ;

Soriano, P ;

Bowen-Pope, DF .

NATURE GENETICS, 1998, 18 (04) :385-388

[7] Isolation of Angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning [J].

Davis, S ;

Aldrich, TH ;

Jones, PF ;

Acheson, A ;

Compton, DL ;

Jain, V ;

Ryan, TE ;

Bruno, J ;

Radziejewski, C ;

Maisonpierre, PC ;

Yancopoulos, GD .

CELL, 1996, 87 (07) :1161-1169

[8] DOMINANT-NEGATIVE AND TARGETED NULL MUTATIONS IN THE ENDOTHELIAL RECEPTOR TYROSINE KINASE, TEK, REVEAL A CRITICAL ROLE IN VASCULOGENESIS OF THE EMBRYO [J].

DUMONT, DJ ;

GRADWOHL, G ;

FONG, GH ;

PURI, MC ;

GERTSENSTEIN, M ;

AUERBACH, A ;

BREITMAN, ML .

GENES & DEVELOPMENT, 1994, 8 (16) :1897-1909

[9] Blood vessel formation: What is its molecular basis? [J].

Folkman, J ;

DAmore, PA .

CELL, 1996, 87 (07) :1153-1155

[10] MESENCHYMAL CONTROL OF BRANCHING PATTERN IN THE FETAL MOUSE LUNG [J].

HILFER, SR ;

RAYNER, RM ;

BROWN, JW .

TISSUE & CELL, 1985, 17 (04) :523-538

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