Treatment of Chronic Migraine

被引：34

作者：

Diener, Hans-Christoph ^{[1
,2
]}

Holle, Dagny ^{[1
,2
]}

Dodick, David ^{[3
]}

机构：

[1] Univ Duisburg Essen, Dept Neurol, D-45147 Essen, Germany

[2] Univ Duisburg Essen, Headache Ctr, D-45147 Essen, Germany

[3] Mayo Clin Arizona, Dept Neurol, Scottsdale, AZ 85259 USA

来源：

CURRENT PAIN AND HEADACHE REPORTS | 2011年 / 15卷 / 01期

关键词：

Chronic migraine; Treatment; Topiramate; Botulinum toxin; CHRONIC DAILY HEADACHE; TOXIN TYPE-A; PLACEBO-CONTROLLED PHASE; DOUBLE-BLIND; EPISODIC MIGRAINE; PROPHYLACTIC TREATMENT; MEDICATION OVERUSE; RISK-FACTORS; TOPIRAMATE; EFFICACY;

D O I：

10.1007/s11916-010-0159-x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Chronic migraine is defined in different ways. The most commonly used definition is headache on more than 15 days per month in patients with migraine. Chronic migraine is difficult to treat and requires a multidisciplinary approach. Only two pharmacological treatments have been shown to be effective in placebo-controlled randomized trials: topiramate and local injection of botulinum toxin. Both therapies are effective in patients with chronic migraine with and without medication overuse. Many other substances have been investigated in chronic daily headache. All trials were underpowered and, therefore, recommendations concerning possible efficacy are not possible.

引用

页码：64 / 69

页数：6

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