Association between homocysteine, vitamin B6 concentrations and inflammation

被引：26

作者：

Gori, Anna Maria ^{[1
]}

Sofi, Francesco ^{[1
]}

Marcucci, Rossella ^{[1
]}

Giusti, Betti ^{[1
]}

Gensini, Gian Franco ^{[1
,2
]}

Abbate, Rosanna ^{[1
]}

机构：

[1] Univ Florence, Dept Med & Surg Crit Care, DeNOTHE Ctr Study Mol & Clin Level Chron Degenera, I-50134 Florence, Italy

[2] IRCCS, Fdn Don Carlo Gnocchi Onlus, Ctr S Maria Agli Ulivi, Florence, Italy

来源：

CLINICAL CHEMISTRY AND LABORATORY MEDICINE | 2007年 / 45卷 / 12期

关键词：

C-reactive protein; homocysteine; inflammation; interleukins; vitamin B-6;

D O I：

10.1515/CCLM.2007.347

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

During the last years, a growing body of evidence has been accumulated on the role of hyperhomocysteinemia in the occurrence of coronary artery disease and other arterial occlusive diseases. The mechanism by which high circulating homocysteine concentrations are a risk factor for atherothrombosis is incompletely understood. The present review is aimed to evaluate the role of inflammation in influencing homocysteine (Hcy) and vitamin B-6 concentrations. Results of a large population-based study have suggested that inflammatory markers are the major determinants of Hcy and vitamin B-6 concentrations. This association, independent of the leading factor, may explain, at least in part, why subjects with high concentrations of Hcy and low concentrations of vitamin B-6 have a high risk of developing cardiovascular diseases.

引用

页码：1728 / 1736

页数：9

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