Hormone Replacement After Breast Cancer: Is It Safe?

被引：5

作者：

Liotta, Margaret ^{[1
]}

Escobar, Pedro F. ^{[1
]}

机构：

[1] Cleveland Clin, Div Gynecol Oncol, Dept Obstet & Gynecol, Cleveland, OH 44106 USA

来源：

CLINICAL OBSTETRICS AND GYNECOLOGY | 2011年 / 54卷 / 01期

关键词：

hormone therapy; breast cancer risk; estrogen; MENOPAUSAL SYMPTOMS; HOT FLUSHES; THERAPY; MANAGEMENT; VENLAFAXINE; TAMOXIFEN; FLASHES; TRIAL; WOMEN; RISK;

D O I：

10.1097/GRF.0b013e3182083cbb

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

The use of hormone therapy for climacteric symptoms in patients with breast cancer has become a significant and important point of discussion due in part to the improved survival from this disease in recent years. There is a theoretic risk that exogenous hormones will stimulate the growth of microscopic disease and lead to decreased survival and increased recurrence. In addition, 2 large studies have shown that there is an association between hormone therapy and breast cancer risk in women without an earlier history of breast cancer. Other studies suggest that estrogen alone may have a superior safety profile than estrogen and progesterone in combination. Hormone therapy could be justified for improvement of quality of life when other options have failed and the patient is informed of the risks.

引用

页码：173 / 179

页数：7

共 20 条

[1] Prospective evaluation of vitamin E for hot flashes in breast cancer survivors [J].

Barton, DL ;

Loprinzi, CL ;

Quella, SK ;

Sloan, JA ;

Veeder, MH ;

Egner, JR ;

Fidler, P ;

Stella, PJ ;

Swan, DK ;

Vaught, NL ;

Novotny, P .

JOURNAL OF CLINICAL ONCOLOGY, 1998, 16 (02) :495-500

[2] Menopausal hormone therapy (HT) in patients with breast cancer [J].

Batur, P ;

Blixen, CE ;

Moore, HCF ;

Thacker, HL ;

Xu, M .

MATURITAS, 2006, 53 (02) :123-132

[3]

Beral Valerie, 2003, Lancet, V362, P419

[4] Menopausal hormone therapy after breast cancer: a meta-analysis and critical appraisal of the evidence [J].

Col, NF ;

Kim, JA ;

Chlebowski, RT .

BREAST CANCER RESEARCH, 2005, 7 (04) :R535-R540

[5]

Dew JE, 2002, CLIMACTERIC, V5, P151

[6] Management of postmenopausal hot flushes with venlafaxine hydrochloride: A randomized, controlled trial [J].

Evans, ML ;

Pritts, E ;

Vittinghoff, E ;

McClish, K ;

Morgan, KS ;

Jaffe, RB .

OBSTETRICS AND GYNECOLOGY, 2005, 105 (01) :161-166

[7] Risk of menopause during the first year after breast cancer diagnosis [J].

Goodwin, PJ ;

Ennis, M ;

Pritchard, KI ;

Trudeau, M ;

Hood, N .

JOURNAL OF CLINICAL ONCOLOGY, 1999, 17 (08) :2365-2370

[8] Prevalence and treatment of menopausal symptoms among breast cancer survivors [J].

Harris, PF ;

Remington, PL ;

Trentham-Dietz, A ;

Allen, CI ;

Newcomb, PA .

JOURNAL OF PAIN AND SYMPTOM MANAGEMENT, 2002, 23 (06) :501-509

[9] Management of menopausal symptoms in patients with breast cancer: an evidence-based approach [J].

Hickey, M ;

Saunders, CM ;

Stuckey, BGA .

LANCET ONCOLOGY, 2005, 6 (09) :687-695

[10] HABITS (hormonal replacement therapy after breast cancer - is it safe?), a randomised comparison: trial stopped [J].

Holmberg, L ;

Anderson, H .

LANCET, 2004, 363 (9407) :453-455

← 1 2 →