In Vivo Biocompatibility Study of Electrospun Chitosan Microfiber for Tissue Engineering

被引：30

作者：

Kang, Yun Mi ^{[1
]}

Lee, Bit Na ^{[1
]}

Ko, Jae Hoon ^{[2
]}

Kim, Gyeong Hae ^{[1
]}

Kang, Kkot Nim ^{[1
]}

Kim, Da Yeon ^{[1
]}

Kim, Jae Ho ^{[1
]}

Park, Young Hwan ^{[2
]}

Chun, Heung Jae ^{[3
]}

Kim, Chun Ho ^{[4
]}

Kim, Moon Suk ^{[1
]}

机构：

[1] Ajou Univ, Dept Mol Sci & Technol, Suwon 443749, South Korea

[2] Korea Inst Ind Technol, Ansan 426791, South Korea

[3] Catholic Univ, Coll Med, Dept Biomed Sci, Seoul 137701, South Korea

[4] Korea Inst Radiol & Med Sci, Lab Tissue Engn, Seoul 139706, South Korea

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2010年 / 11卷 / 10期

关键词：

electrospun; chitosan; microfibers; scaffold; stem cell; OSTEOGENIC DIFFERENTIATION; STEM-CELLS; SCAFFOLD;

D O I：

10.3390/ijms11104140

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this work, we examined the biocompatibility of electrospun chitosan microfibers as a scaffold. The chitosan microfibers showed a three-dimensional pore structure by SEM. The chitosan microfibers supported attachment and viability of rat muscle-derived stem cells (rMDSCs). Subcutaneous implantation of the chitosan microfibers demonstrated that implantation of rMDSCs containing chitosan microfibers induced lower host tissue responses with decreased macrophage accumulation than did the chitosan microfibers alone, probably due to the immunosuppression of the transplanted rMDSCs. Our results collectively show that chitosan microfibers could serve as a biocompatible in vivo scaffold for rMDSCs in rats.

引用

页码：4140 / 4148

页数：9

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