Spatial Relation Between Microbleeds and Amyloid Deposits in Amyloid Angiopathy

被引:181
作者
Dierksen, Gregory A. [1 ]
Skehan, Maureen E. [1 ]
Khan, Muhammad A. [1 ]
Jeng, Jed [1 ]
Nandigam, R. N. Kaveer [1 ]
Becker, John A. [2 ]
Kumar, Ashok [1 ]
Neal, Krista L.
Betensky, Rebecca A. [3 ]
Frosch, Matthew P. [4 ]
Rosand, Jonathan [1 ]
Johnson, Keith A. [2 ]
Viswanathan, Anand [1 ]
Salat, David H. [2 ]
Greenberg, Steven M. [1 ]
机构
[1] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Hemorrhag Stroke Res Program,Dept Neurol, Boston, MA 02115 USA
[2] Harvard Univ, Sch Med, Dept Radiol, Massachusetts Gen Hosp, Boston, MA 02115 USA
[3] Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA
[4] Harvard Univ, Massachusetts Gen Hosp, Sch Med, CS Kubik Lab Neuropathol, Boston, MA USA
基金
美国国家卫生研究院;
关键词
PITTSBURGH COMPOUND-B; CEREBRAL MICROBLEEDS; ALZHEIMERS-DISEASE; BRAIN; BETA; IMMUNOTHERAPY; DEMENTIA;
D O I
10.1002/ana.22099
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Advanced cerebrovascular beta-amyloid deposition (cerebral amyloid angiopathy, CAA) is associated with cerebral microbleeds, but the precise relationship between CAA burden and microbleeds is undefined. We used T2(star)-weighted magnetic resonance imaging (MRI) and noninvasive amyloid imaging with Pittsburgh Compound B (PiB) to analyze the spatial relationship between CAA and microbleeds. On coregistered positron emission tomography (PET) and MRI images, PiB retention was increased at microbleed sites compared to simulated control lesions (p = 0.002) and declined with increasing distance from the microbleed (p < 0.0001). These findings indicate that microbleeds occur preferentially in local regions of concentrated amyloid and support therapeutic strategies aimed at reducing vascular amyloid deposition. ANN NEUROL 2010;68:545-548
引用
收藏
页码:545 / 548
页数:4
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