An amyloid-like fibril forming antiparallel supramolecular β-sheet from a synthetic tripeptide:: a crystallographic signature

被引：25

作者：

Banerjee, A ^{[1
]}

Maji, SK

Drew, MGB

Haldar, D

Banerjee, A ^{[1
]}

机构：

[1] Indian Assoc Cultivat Sci, Dept Biol Chem, Kolkata 700032, W Bengal, India

[2] Univ Reading, Dept Chem, Reading RG6 6AD, Berks, England

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 35期

基金：

英国工程与自然科学研究理事会;

关键词：

Aib; antiparallel beta-sheet; amyloid-like fibrils; self-assembly;

D O I：

10.1016/S0040-4039(03)01642-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Single crystal X-ray diffraction studies of a terminally blocked tripeptide Boc-Leu(1)-Aib(2)-Leu(3)-OMe 1 demonstrates that it adopts a bend structure without any intramolecular hydrogen bond. Peptide 1 self-assembles to form a supramolecular antiparallel beta-sheet structure by various non-covalent interactions including intermolecular hydrogen bonds in the crystal and it exhibits amyloid-like fibrillar morphology in the solid state. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：6741 / 6744

页数：4

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