Maternal caesarean section infection (MACSI) in Sierra Leone: a case-control study

被引：35

作者：

Di Gennaro, F. ^{[1
,2
]}

Marotta, C. ^{[2
,3
]}

Pisani, L. ^{[2
,3
,4
]}

Veronese, N. ^{[5
]}

Pisani, V ^{[3
]}

Lippolis, V ^{[6
]}

Pellizer, G. ^{[2
]}

Pizzol, D. ^{[2
]}

Tognon, F. ^{[2
]}

Bavaro, D. F. ^{[1
]}

Oliva, F. ^{[3
]}

Ponte, S. ^{[3
]}

Bruce, P. Nanka ^{[7
]}

Monno, L. ^{[1
]}

Saracino, A. ^{[1
]}

Koroma, M. M. ^{[8
]}

Putoto, G. ^{[2
]}

机构：

[1] Univ Bari, Clin Infect Dis, Bari, Italy

[2] Africa CUAMM, Operat Res Unit, Padua, Italy

[3] Africa CUAMM, Operat Res Unit, Freetown, Sierra Leone

[4] Univ Amsterdam, Med Ctr, AMC, Dept Intens Care, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands

[5] Unita Locale Socio Sanitaria 3 Serenissima, Primary Care Dept, Venice, Italy

[6] Mater Hosp, Bari, Italy

[7] United Nations Populat Fund, UNFPA, Freetown, Sierra Leone

[8] PCMH, Freetown, Sierra Leone

来源：

EPIDEMIOLOGY AND INFECTION | 2020年 / 148卷

关键词：

Antibiotic; maternal death; Sierra Leone; surgical site infection; SURGICAL SITE INFECTIONS; DELIVERY; TIME;

D O I：

10.1017/S0950268820000370

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Sierra Leone is the country with highest maternal mortality and infections are the underlying cause in 11% of maternal deaths, but the real burden remains unknown. This study aims to determine the incidence and risk factors of surgical site infection (SSI) post-caesarean section (CS) in women admitted to Princess Christian Maternity Hospital (PCMH) in Freetown, Sierra Leone. A prospective case-control (1:3 ratio) study was implemented from 1 May 2018 to 30 April 2019 and 11 women presenting with suspected or confirmed infection post-CS were screened for inclusion as a case. For each case, three patients undergoing CS on the same day and admitted to the same ward, but not presenting with SSI, were selected as controls. The post-CS infection rate was 10.9%. Two hundred and fifty-four clinically confirmed cases were enrolled and matched with 762 control patients. By multivariable analysis, the risk factors for SSI were: being single (odds ratio (OR) 1.48, 95% confidence interval (CI) 1.36-1.66), low education level (OR 1.68, 95% CI 1.55-1.84), previous CS (OR 1.27, 95% CI 1.10-1.52), presenting with premature membranes rupture (OR 1.49, 95% CI 1.18-1.88), a long decision-incision time (OR 2.08, 95% CI 1.74-2.24) and a high missing post-CS antibiotic doses rate (OR 2.52, 95% CI 2.10-2.85).

引用

页数：6