Long-term selective IgG immunoadsorption improves Rasmussen's encephalitis

被引：80

作者：

Antozzi, C

Granata, T

Aurisano, N

Zardini, G

Confalonieri, P

Airaghi, G

Mantegazza, R

Spreafico, R

机构：

[1] Ist Nazl Neurol Carlo Besta, Neuromuscular Res Dept, I-20133 Milan, Italy

[2] Ist Nazl Neurol Carlo Besta, Dept Child Neurol, I-20133 Milan, Italy

[3] Ist Nazl Neurol Carlo Besta, Dept Expt Neurophysiol & Epileptol, I-20133 Milan, Italy

[4] Ist Nazl Neurol Carlo Besta, Language Disorder Unit, I-20133 Milan, Italy

来源：

NEUROLOGY | 1998年 / 51卷 / 01期

关键词：

D O I：

10.1212/WNL.51.1.302

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We report that long-term selective immunoglobulin G immunoadsorption by protein A (PAI) improved seizure frequency and neuropsychological deficits in a 16-year-old patient with severe treatment-resistant Rasmussen's encephalitis (RE). Clinical improvement correlated with reduction of antiglutamate receptor 3 antibodies. The efficacy of PAI in our patient supports the autoimmune hypothesis of RE and suggests its application to avoid, or at least delay, functional hemispherectomy in selected cases.

引用

页码：302 / 305

页数：4

共 8 条

[1] Plasmapheresis in Rasmussen's encephalitis [J].