Optical coherence photoacoustic microscopy (OC-PAM) with an intensity-modulated continuous-wave broadband light source

被引：0

作者：

Liu, Xiaojing ^{[1
]}

Wen, Rong ^{[2
]}

Li, Yiwen ^{[2
]}

Jiao, Shuliang ^{[1
]}

机构：

[1] Florida Int Univ, Dept Biomed Engn, Miami, FL 33174 USA

[2] Univ Miami, Sch Med, Bascom Palmer Eye Inst, Miami, FL 33136 USA

来源：

JOURNAL OF OPTICS | 2016年 / 18卷 / 06期

基金：

美国国家卫生研究院;

关键词：

optical coherence tomography; photoacoustic imaging; biomedical optics; multimodal imaging; IN-VIVO; HIGH-SENSITIVITY; TOMOGRAPHY; RESOLUTION; OPHTHALMOSCOPY;

D O I：

10.1088/2040-8978/18/6/064001

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

We developed an optical coherence photoacoustic microscopy system using an intensity-modulated continuous-wave superluminescent diode with a center wavelength of 840 nm. The system can accomplish optical coherence tomography (OCT) and photoacoustic microscopy (PAM) simultaneously. Compared to the system with a pulsed light source, this system is able to achieve OCT imaging with quality as high as conventional spectral-domain OCT. Since both of the OCT and PAM images are generated from the same group of photons, they are intrinsically registered in the lateral directions. The system was tested for multimodal imaging the vasculature of mouse ear in vivo by using gold nanorods as contrast agent for PAM, as well as excised porcine eyes ex vivo. The OCT and PAM images showed complimentary information of the sample.

引用

页数：6

共 25 条

[1] Targeted gold nanorod contrast agent for prostate cancer detection by photoacoustic imaging [J].

Agarwal, A. ;

Huang, S. W. ;

O'Donnell, M. ;

Day, K. C. ;

Day, M. ;

Kotov, N. ;

Ashkenazi, S. .

JOURNAL OF APPLIED PHYSICS, 2007, 102 (06)

[2] High sensitivity of in vivo detection of gold nanorods using a laser optoacoustic imaging system [J].

Eghtedari, Mohammad ;

Oraevsky, Alexander ;

Copland, John A. ;

Kotov, Nicholas A. ;

Conjusteau, Andre ;

Motamedi, Massoud .

NANO LETTERS, 2007, 7 (07) :1914-1918

[3] Engineering of Hetero-Functional Gold Nanorods for the in vivo Molecular Targeting of Breast Cancer Cells [J].

Eghtedari, Mohammad ;

Liopo, Anton V. ;

Copland, John A. ;

Oraevslty, Alexander A. ;

Motamedi, Massoud .

NANO LETTERS, 2009, 9 (01) :287-291

[4] Photoacoustic imaging and characterization of the microvasculature [J].

Hu, Song ;

Wang, Lihong V. .

JOURNAL OF BIOMEDICAL OPTICS, 2010, 15 (01)

[5] OPTICAL COHERENCE TOMOGRAPHY [J].

HUANG, D ;

SWANSON, EA ;

LIN, CP ;

SCHUMAN, JS ;

STINSON, WG ;

CHANG, W ;

HEE, MR ;

FLOTTE, T ;

GREGORY, K ;

PULIAFITO, CA ;

FUJIMOTO, JG .

SCIENCE, 1991, 254 (5035) :1178-1181

[6] In vivo bidirectional color Doppler flow imaging of picoliter blood volumes using optical coherence tomograghy [J].

Izatt, JA ;

Kulkami, MD ;

Yazdanfar, S ;

Barton, JK ;

Welch, AJ .

OPTICS LETTERS, 1997, 22 (18) :1439-1441

[7] Photoacoustic ophthalmoscopy for in vivo retinal imaging [J].

Jiao, Shuliang ;

Jiang, Minshan ;

Hu, Jianming ;

Fawzi, Amani ;

Zhou, Qifa ;

Shung, K. Kirk ;

Puliafito, Carmen A. ;

Zhang, Hao F. .

OPTICS EXPRESS, 2010, 18 (04) :3967-3972

[8] Simultaneous multimodal imaging with integrated photoacoustic microscopy and optical coherence tomography [J].

Jiao, Shuliang ;

Xie, Zhixing ;

Zhang, Hao F. ;

Puliafito, Carmen A. .

OPTICS LETTERS, 2009, 34 (19) :2961-2963

[9] Photoacoustic imaging of early inflammatory response using gold nanorods [J].

Kim, Kang ;

Huang, Sheng-Wen ;

Ashkenazi, Shai ;

O'Donnell, Matthew ;

Agarwal, Ashish ;

Kotov, Nicholas A. ;

Denny, Michael F. ;

Kaplan, Mariana J. .

APPLIED PHYSICS LETTERS, 2007, 90 (22)

[10] Three-dimensional combined photoacoustic and optical coherence microscopy for in vivo microcirculation studies [J].

Li, Li ;

Maslov, Konstantin ;

Ku, Geng ;

Wang, Lihong V. .

OPTICS EXPRESS, 2009, 17 (19) :16450-16455

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