The anti-inflammatory effect of Ilex paraguariensis A. St. Hil (Mate) in a murine model of pleurisy

被引：28
|
作者：
Gobbo Luz, Ana Beatriz [1 ]
Blum da Silva, Carlos Henrique [2 ]
Nascimento, Marcus Vinicius P. S. [1 ]
de Campos Facchin, Bruno Matheus [1 ]
Baratto, Bruna [1 ]
Frode, Tanta Silvia [1 ]
Reginatto, Flavio Henrique [2 ]
Dalmarco, Eduardo Monguilhott [1 ,3 ]
机构：
[1] Univ Fed Santa Catarina, Ctr Hlth Sci, Dept Clin Anal, Campus Univ Trindade, BR-88040900 Florianopolis, SC, Brazil
[2] Univ Fed Santa Catarina, Ctr Hlth Sci, Dept Pharmaceut Sci, BR-88040900 Florianopolis, SC, Brazil
[3] Univ Turin, Ctr Mol Biotechnol, Dept Mol Biotechnol & Hlth Sci, I-10124 Turin, Italy
来源：
INTERNATIONAL IMMUNOPHARMACOLOGY | 2016年 / 36卷
关键词：
Ilex paraguariensis; Carrageenan; Pleurisy; Th1/Th17; polarization; Anti-inflammatory; NF-KAPPA-B; NITRIC-OXIDE SYNTHASE; QUANTITATIVE-ANALYSIS; INFLAMMATION; CARRAGEENAN; MICE; ACTIVATION; ADENOSINE; EXTRACTS; LEAVES;
D O I：
10.1016/j.intimp.2016.04.027
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Ilex paraguariensis is a native plant from Southern America, where it is used as a beverage. In traditional medicine, it is used to treat many diseases including inflammation. However, we do not yet know precisely how this effect occurs. We therefore evaluated its anti-inflammatory effect in a murine model of pleurisy. The standardized CE, BF and ARF fractions, Caf, Rut and CGA were able to reduce leukocyte migration, exudate concentration, MPO and ADA activities and NOx levels. Moreover, I. paraguariensis also inhibited the release of Th1/Th17 pro inflammatory cytokines, while increasing IL-10 production and improving the histological architecture of inflamed lungs. In addition, its major compounds decreased p65 NF-kappa B phosphorylation. Based on our results, we can conclude that I. paraguariensis exerts its anti-inflammatory action by attenuating the Th1/Th17 polarization in this model. This fact suggests that the use of this plant as a beverage can protect against Th1/Th17 inflammatory diseases. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码：165 / 172
页数：8
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