DNA Damage in Chronic Kidney Disease: Evaluation of Clinical Biomarkers

被引：41
作者：
Schupp, Nicole [1 ]
Stopper, Helga [2 ]
Heidland, August [3 ]
机构：
[1] Univ Dusseldorf, Fac Med, Inst Toxicol, D-40225 Dusseldorf, Germany
[2] Univ Wurzburg, Inst Pharmacol & Toxicol, D-97078 Wurzburg, Germany
[3] Univ Wurzburg, Dept Internal Med, D-97080 Wurzburg, Germany
来源：
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY | 2016年 / 2016卷
关键词：
BLOCK MICRONUCLEUS ASSAY; STAGE RENAL-DISEASE; PERIPHERAL-BLOOD LYMPHOCYTES; SISTER-CHROMATID EXCHANGES; OXIDATIVE STRESS; COMET-ASSAY; MITOCHONDRIAL-DNA; GENOMIC DAMAGE; SCORING CRITERIA; CYTOGENETIC BIOMARKERS;
D O I：
10.1155/2016/3592042
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Patients with chronic kidney disease (CKD) exhibit an increased cancer risk compared to a healthy control population. To be able to estimate the cancer risk of the patients and to assess the impact of interventional therapies thereon, it is of particular interest to measure the patients' burden of genomic damage. Chromosomal abnormalities, reduced DNA repair, and DNA lesions were found indeed in cells of patients with CKD. Biomarkers for DNA damage measurable in easily accessible cells like peripheral blood lymphocytes are chromosomal aberrations, structural DNA lesions, and oxidatively modified DNA bases. In this review the most common methods quantifying the three parameters mentioned above, the cytokinesis-block micronucleus assay, the comet assay, and the quantification of 8-oxo-7,8-dihydro-2'-deoxyguanosine, are evaluated concerning the feasibility of the analysis and regarding the marker's potential to predict clinical outcomes.
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页数：10
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