Effects of Weight Loss Among Metabolically Healthy Obese Men and Women

被引：92

作者：

Janiszewski, Peter M. ^{[1
]}

Ross, Robert ^{[1
,2
]}

机构：

[1] Queens Univ, Sch Kinesiol & Hlth Studies, Kingston, ON, Canada

[2] Queens Univ, Div Endocrinol & Metab, Sch Med, Kingston, ON, Canada

来源：

DIABETES CARE | 2010年 / 33卷 / 09期

基金：

加拿大健康研究院;

关键词：

INSULIN-RESISTANCE; REDUCTION;

D O I：

10.2337/dc10-0547

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

OBJECTIVE - Weight loss among metabolically healthy obese (MHO) individuals may be unnecessary or result in elevated cardio-metabolic risk. We studied the effects of exercise- or diet-induced weight loss on cardio-metabolic risk among MHO and metabolically abnormal obese (MAO) adults. RESEARCH DESIGN AND METHODS - Participants were 63 MHO and 43 MAO adults who took part in 3 to 6 months of exercise- or diet-induced weight loss intervention. Changes in anthropometry, adipose tissue distribution, and cardio-metabolic risk factors were assessed. RESULTS - Body weight, waist circumference, and total abdominal and visceral adipose tissue were reduced in all subjects (P < 0.05). Improvements in insulin sensitivity were observed in MHO and MAO men and women (P < 0.05), but were greater in the MAO individuals (P < 0.05). Fasting insulin was the only other cardio-metabolic improvement among MHO individuals (P < 0.05). CONCLUSIONS - Lifestyle-induced weight loss among MHO subjects is associated with a reduction in total and abdominal obesity and improvement in selected cardio-metabolic risk

引用

页码：1957 / 1959

页数：3

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