Improved survival of colon cancer due to improved treatment and detection: a nationwide population-based study in The Netherlands 1989-2006

被引:94
作者
van Steenbergen, L. N. [1 ]
Elferink, M. A. G. [2 ]
Krijnen, P. [3 ]
Lemmens, V. E. P. P. [1 ,4 ]
Siesling, S. [2 ,5 ]
Rutten, H. J. T. [6 ]
Richel, D. J. [7 ]
Karim-Kos, H. E. [4 ]
Coebergh, J. W. W. [1 ,4 ]
机构
[1] Comprehens Canc Ctr S, Eindhoven Canc Registry, Dept Res, NL-5600 AE Eindhoven, Netherlands
[2] Comprehens Canc Ctr NE, Dept Res, Enschede, Netherlands
[3] Comprehens Canc Ctr W, Leiden, Netherlands
[4] Erasmus MC Univ Med Ctr, Dept Publ Hlth, Rotterdam, Netherlands
[5] Univ Twente, Dept Hlth Technol & Serv Res, Enschede, Netherlands
[6] Catharina Hosp, Dept Surg, Eindhoven, Netherlands
[7] Acad Med Ctr Amsterdam, Dept Internal Med, Amsterdam, Netherlands
关键词
chemotherapy; colon cancer; population-based; survival; ADJUVANT THERAPY; ELDERLY-PATIENTS; ROGERS; WILL PHENOMENON; COLORECTAL-CANCER; PLUS LEVAMISOLE; POOLED ANALYSIS; STAGE-II; FLUOROURACIL; CHEMOTHERAPY; CARCINOMA;
D O I
10.1093/annonc/mdq227
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: We described changes in treatment of colon cancer over time and the impact on survival in The Netherlands in the period 1989-2006. Patients and methods: All 103 744 patients with invasive colon cancer during 1989-2006 in The Netherlands were included. Data were extracted from The Netherlands Cancer Registry. Trends in treatment over time were analysed and multivariable relative survival analysis was carried out. Results: The administration of adjuvant chemotherapy in stage III patients <75 years increased from 19% in 1989-1993 to 79% in 2004-2006 and from 1% to 19% in stage III patients >= 75 years. Among stage IV patients, resection rates of the primary tumour decreased from 72% to 63%, while chemotherapy administration increased from 23% to 64% in those <75 years. Survival increased from 52% to 58% in males and from 55% to 58% among females. Stage III patients with adjuvant chemotherapy exhibited a relative excess risk of 0.4 (95% confidence interval 0.4-0.4) compared with those without. Among stage IV patients, resection of primary tumour, palliative chemotherapy, and metastasectomy were important prognostic factors. Conclusions: There were substantial improvements in management and survival of colon cancer from 1989 to 2006. Stage III disease patients with colon cancer experienced the largest improvement in survival, most likely related to the increased administration of adjuvant chemotherapy.
引用
收藏
页码:2206 / 2212
页数:7
相关论文
共 31 条
  • [1] Patient age and comorbidity are major determinants of adjuvant chemotherapy use for stage III colon cancer in routine clinical practice
    Ananda, Sumitra
    Field, Kathryn M.
    Kosmider, Suzanne
    Compston, Daniel
    Desai, Jayesh
    Lim, Lionel C.
    Barnett, Frances S.
    Jones, Ian T.
    Skinner, Iain
    Gibbs, Peter
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (27) : 4516 - 4517
  • [2] [Anonymous], 2013, International Classification of disease for Oncology
  • [3] Cancer patients, doctors and nurses vary in their willingness to undertake cancer chemotherapy
    Bremnes, RM
    Andersen, K
    Wist, EA
    [J]. EUROPEAN JOURNAL OF CANCER, 1995, 31A (12) : 1955 - 1959
  • [4] Adjuvant therapy in colon cancer: current status and future directions cancer
    Chau, I
    Cunningham, D
    [J]. CANCER TREATMENT REVIEWS, 2002, 28 (05) : 223 - 236
  • [5] Comorbidity and colorectal cancer according to subsite and stage: a population-based study
    De Marco, MF
    Janssen-Heijnen, MLG
    van der Heijden, LH
    Coebergh, JWW
    [J]. EUROPEAN JOURNAL OF CANCER, 2000, 36 (01) : 95 - 99
  • [6] Regression models for relative survival
    Dickman, PW
    Sloggett, A
    Hills, M
    Hakulinen, T
    [J]. STATISTICS IN MEDICINE, 2004, 23 (01) : 51 - 64
  • [7] Overcoming challenges associated with chemotherapy treatment in the senior adult population
    Droz, Jean-Pierre
    Aapro, Matti
    Balducci, Lodovico
    [J]. CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 2008, 68 : S1 - S8
  • [8] Ederer FHH., 1959, INSTRUCTIONS IBM 650
  • [9] Rates and Predictors of Chemotherapy Use for Stage III Colon Cancer A Systematic Review
    Etzioni, David A.
    El-Khoueiry, Anthony B.
    Beart, Robert W., Jr.
    [J]. CANCER, 2008, 113 (12) : 3279 - 3289
  • [10] Colon cancer in France: evidence for improvement in management and survival
    Faivre-Finn, C
    Bouvier-Benhamiche, AM
    Phelip, JM
    Manfredi, S
    Dancourt, V
    Faivre, J
    [J]. GUT, 2002, 51 (01) : 60 - 64