Bisphosphonates Induce Apoptosis of Circulating Endothelial Cells in Multiple Myeloma Patients and in Subjects with Bisphosphonate-Induced Osteonecrosis of the Jaws

被引：35

作者：

Allegra, Alessandro ^{[1
]}

Alonci, Andrea ^{[1
]}

Penna, Giuseppa ^{[1
]}

Granata, Angela ^{[1
]}

Siniscalchi, Enrico Nastro ^{[2
]}

Oteri, Giacomo ^{[3
]}

Loddo, Saverio ^{[4
]}

Teti, Diana ^{[4
]}

Ciccu, Domenico ^{[3
]}

De Ponte, Francesco Saverio ^{[2
]}

Musolino, Caterina ^{[1
]}

机构：

[1] Univ Messina, Div Hematol, IT-98100 Messina, Italy

[2] Univ Messina, Div Oral & Maxillofacial Surg, IT-98100 Messina, Italy

[3] Univ Messina, Dept Dent, IT-98100 Messina, Italy

[4] Univ Messina, Dept Pathol & Expt Microbiol, IT-98100 Messina, Italy

来源：

ACTA HAEMATOLOGICA | 2010年 / 124卷 / 02期

关键词：

Annexin V; Apoptosis; Bisphosphonates; Circulating endothelial cell; Multiple myeloma; Osteonecrosis; BREAST-CANCER PATIENTS; ANGIOGENIC FACTORS; ZOLEDRONIC-ACID; EXPERT PANEL; EXPRESSION; DENSITY; GROWTH; GENE; RATS; VEGF;

D O I：

10.1159/000313787

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Bisphosphonates (BPs) are the current standard of care for bone lesions in patients with multiple myeloma (MM) but they are associated with a number of side effects such as osteonecrosis of the jaw. The exact mechanisms of osteonecrosis are not elucidated, and its physiopathology is based on several hypotheses such as a decrease in bone remodeling or an inhibitory effect on angiogenesis. The aim of our study was to investigate the mechanism involved in the pathogenesis of osteonecrosis. We examined the apoptosis of circulating endothelial progenitor cells in MM subjects before and after BP treatment and in osteonecrosis patients using a flow-cytometric analysis. Our data showed an increase in endothelial cell apoptosis in MM patients after BP administration and in osteonecrosis subjects. Our study seems in agreement with the hypothesis that BPs can inhibit angiogenesis interfering with endothelial cell proliferation and survival, leading to loss of blood vessels and avascular necrosis. Copyright (c) 2010 S. Karger AG, Basel

引用

页码：79 / 85

页数：7

共 40 条

[1] Patients with bisphosphonates-associated osteonecrosis of the jaw have reduced circulating endothelial cells [J].