Putting a finger on the switch

被引：19

作者：

Bieker, James J. ^{[1
]}

机构：

[1] Mt Sinai Sch Med, Dept Dev & Regenerat Biol, New York, NY 10029 USA

来源：

NATURE GENETICS | 2010年 / 42卷 / 09期

关键词：

KRUPPEL-LIKE FACTOR; GLOBIN;

D O I：

10.1038/ng0910-733

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The transition from fetal to adult beta-like globin expression is a key step in the maturation of the red blood cell lineage. Two new studies show that the KLF1 zinc finger protein uses direct and indirect means to regulate the final switch from fetal to adult globin expression and that monoallelic loss of KLF1 expression leads to persistence of fetal hemoglobin.

引用

页码：733 / 734

页数：2

共 12 条

[1] BIEKER JJ, 2001, TRANSCRIPTION FACTOR
[2] Haploinsufficiency for the erythroid transcription factor KLF1 causes hereditary persistence of fetal hemoglobin
Borg, Joseph
Papadopoulos, Petros
Georgitsi, Marianthi
Gutierrez, Laura
Grech, Godfrey
Fanis, Pavlos
Phylactides, Marios
Verkerk, Annemieke J. M. H.
van der Spek, Peter J.
Scerri, Christian A.
Cassar, Wilhelmina
Galdies, Ruth
van IJcken, Wilfred
Ozgur, Zeliha
Gillemans, Nynke
Hou, Jun
Bugeja, Marisa
Grosveld, Frank G.
von Lindern, Marieke
Felice, Alex E.
Patrinos, George P.
Philipsen, Sjaak
[J]. NATURE GENETICS, 2010, 42 (09) : 801 - U100
[3] ROLE OF ERYTHROID KRUPPEL-LIKE FACTOR IN HUMAN GAMMA-GLOBIN TO BETA-GLOBIN GENE SWITCHING
DONZE, D
TOWNES, TM
BIEKER, JJ
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (04) : 1955 - 1959
[4] Genetic architecture of hemoglobin F control
Menzel, Stephan
Thein, Swee Lay
[J]. CURRENT OPINION IN HEMATOLOGY, 2009, 16 (03) : 179 - 186
[5] Erythroid Kruppel like factor: from fishing expedition to gourmet meal
Perkins, A
[J]. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 1999, 31 (10) : 1175 - 1192
[6] Developmental and species-divergent globin switching are driven by BCL11A
Sankaran, Vijay G.
Xu, Jian
Ragoczy, Tobias
Ippolito, Gregory C.
Walkley, Carl R.
Maika, Shanna D.
Fujiwara, Yuko
Ito, Masafumi
Groudine, Mark
Bender, M. A.
Tucker, Philip W.
Orkin, Stuart H.
[J]. NATURE, 2009, 460 (7259) : 1093 - 1097
[7] Severe anemia in the Nan mutant mouse caused by sequence-selective disruption of erythroid Kruppel-like factor
Siatecka, Miroslawa
Sahr, Kenneth E.
Andersen, Sabra G.
Mezei, Mihaly
Bieker, James J.
Peters, Luanne L.
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (34) : 15151 - 15156
[8] Mutations in EKLF/KLF1 form the molecular basis of the rare blood group In(Lu) phenotype
Singleton, Belinda K.
Burton, Nicholas M.
Green, Carole
Brady, R. Leo
Anstee, David J.
[J]. BLOOD, 2008, 112 (05) : 2081 - 2088
[9] Stamatoyannopoulos G., 2001, MOL BASIS BLOOD DIS, V3rd
[10] WEATHERALL DJ, 2001, MOL BASIS BLOOD DIS

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