N-Methyl substituted 2′,4′-BNANC:: a highly nuclease-resistant nucleic acid analogue with high-affinity RNA selective hybridization

被引：38

作者：

Miyashita, Kazuyuki

Rahman, S. M. Abdur

Seki, Sayori

Obika, Satoshi

Imanishi, Takeshi

机构：

[1] Osaka Univ, Grad Sch Pharmaceut Sci, Suita, Osaka 5650871, Japan

[2] PRESTO, Japan Sci & Technol Agcy, Kawaguchi, Saitama 3320012, Japan

来源：

CHEMICAL COMMUNICATIONS | 2007年 / 36期

关键词：

D O I：

10.1039/b707352f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Oligonucleotides modified with a novel BNA analogue, 29, 4'-BNA(NC)[N-Me], were synthesized, and in comparison to 2',4'- BNA (LNA), have similarly high RNA affinity, better RNA selectivity and much higher resistance to nuclease degradation, suggesting that the novel BNA analogue may be particularly useful for antisense approaches.

引用

页码：3765 / 3767

页数：3

共 33 条

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