Solid-phase synthesis of metal-complex containing peptides

被引：19

作者：

Dirscherl, Georg

Knape, Robert

Hanson, Paul

Koenig, Burkhard

机构：

[1] Univ Regensburg, Inst Organ Chem, D-93040 Regensburg, Germany

[2] Univ Kansas, Dept Chem, Lawrence, KS 66045 USA

来源：

TETRAHEDRON | 2007年 / 63卷 / 23期

关键词：

solid-phase peptide synthesis; metal complex; single amino acid chelate;

D O I：

10.1016/j.tet.2007.03.147

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We report the synthesis of Fmoc protected single amino acid chelates (SAAC) and their metal complexes. The modified amino acids are suitable for solid-phase peptide synthesis. The use of 4-hydroxymethylbenzoic acid AM (HMBA-AM) resin allows the nucleophilic cleavage of the peptide-metal complexes from the resin without decomplexation. (c) 2007 Elsevier Ltd. All rights reserved.

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收藏

页码：4918 / 4928

页数：11

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