Solid-phase synthesis of metal-complex containing peptides

被引：19
作者：
Dirscherl, Georg
Knape, Robert
Hanson, Paul
Koenig, Burkhard
机构：
[1] Univ Regensburg, Inst Organ Chem, D-93040 Regensburg, Germany
[2] Univ Kansas, Dept Chem, Lawrence, KS 66045 USA
来源：
TETRAHEDRON | 2007年 / 63卷 / 23期
关键词：
solid-phase peptide synthesis; metal complex; single amino acid chelate;
D O I：
10.1016/j.tet.2007.03.147
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
We report the synthesis of Fmoc protected single amino acid chelates (SAAC) and their metal complexes. The modified amino acids are suitable for solid-phase peptide synthesis. The use of 4-hydroxymethylbenzoic acid AM (HMBA-AM) resin allows the nucleophilic cleavage of the peptide-metal complexes from the resin without decomplexation. (c) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4918 / 4928
页数：11
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