Circulating vitamin D in relation to cancer incidence and survival of the head and neck and oesophagus in the EPIC cohort

被引：37

作者：

Fanidi, Anouar ^{[1
]}

Muller, David C. ^{[1
]}

Midttun, Oivind ^{[2
]}

Ueland, Per Magne ^{[3
,4
]}

Vollset, Stein Emil ^{[5
,6
]}

Relton, Caroline ^{[7
]}

Vineis, Paolo ^{[8
,9
]}

Weiderpass, Elisabete ^{[10
]}

Skeie, Guri ^{[10
,11
]}

Brustad, Magritt ^{[10
,11
]}

Palli, Domenico ^{[12
]}

Tumino, Rosario ^{[13
]}

Grioni, Sara ^{[14
]}

Sacerdote, Carlotta ^{[15
]}

Bueno-de-Mesquita, H. B. ^{[16
,17
]}

Peeters, Petra H. ^{[18
]}

Boutron-Ruault, Marie-Christine ^{[19
,20
,21
]}

Kvaskoff, Marina ^{[19
,20
,21
]}

Cadeau, Claire ^{[19
,20
,21
]}

Maria Huerta, Jose ^{[22
,23
]}

Sanchez, Maria-Jose ^{[22
,24
]}

Agudo, Antonio ^{[25
]}

Lasheras, Cristina ^{[26
]}

Ramon Quiros, J. ^{[27
]}

Chamosa, Saioa ^{[28
]}

Riboli, Elio ^{[8
]}

Travis, Ruth C. ^{[29
]}

Ward, Heather ^{[8
]}

Murphy, Neil ^{[8
]}

Khaw, Kay-Tee ^{[30
]}

Trichopoulou, Antonia ^{[31
,32
]}

Lagiou, Pagona ^{[32
,33
,34
]}

Papatesta, Eleni-Maria ^{[31
]}

Boeing, Heiner ^{[35
]}

Kuehn, Tilman ^{[36
]}

Katzke, Verena ^{[36
]}

Steffen, Annika ^{[35
]}

Johansson, Anders ^{[37
]}

Brennan, Paul ^{[1
]}

Johansson, Mattias ^{[1
]}

机构：

[1] Int Agcy Res Canc, Lyon, France

[2] Bevital AS, Bergen, Norway

[3] Univ Bergen, Inst Med, Pharmacol Sect, Bergen, Norway

[4] Haukeland Hosp, Lab Clin Biochem, Bergen, Norway

[5] Univ Bergen, Dept Publ Hlth & Primary Hlth Care, Bergen, Norway

[6] Norwegian Inst Publ Hlth, Div Epidemiol, Bergen, Norway

[7] Newcastle Univ, Inst Ageing & Hlth, Newcastle Upon Tyne, Tyne & Wear, England

[8] Imperial Coll London, Sch Publ Hlth, London, England

[9] HuGeF Fdn, Turin, Italy

[10] Univ Tromso, Fac Hlth Sci, Dept Community Med, Tromso, Norway

[11] Arctic Univ Norway, Tromso, Norway

[12] Canc Res & Prevent Inst ISPO, Mol & Nutr Epidemiol Unit, Florence, Italy

[13] ASP Ragusa, Civile MP Arezzo Hosp, Canc Registry & Histopathol Unit, Ragusa, Italy

[14] Fdn IRCCS Ist Nazl Tumori, Epidemiol & Prevent Unit, Milan, Italy

[15] CPO Piemonte & HuGeF Fdn, Turin, Italy

[16] Natl Inst Publ Hlth & Environm RIVM, Bilthoven, Netherlands

[17] Univ Med Ctr, Dept Gastroenterol & Hepatol, Utrecht, Netherlands

[18] Univ Med Ctr, Julius Ctr Hlth Sci & Primary Care, Dept Epidemiol, Utrecht, Netherlands

[19] INSERM, Ctr Res Epidemiol & Populat Hlth CESP, Nutr Hormones & Womens Hlth Team, U1018, Villejuif, France

[20] Univ Paris Sud, UMRS 1018, Villejuif, France

[21] Inst Gustave Roussy, Villejuif, France

[22] Consortium Biomed Res Epidemiol & Publ Hlth, CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain

[23] Murcia Reg Hlth Council, Dept Epidemiol, Murcia, Spain

[24] Andalusian Sch Publ Hlth, Granada, Spain

[25] Catalan Inst Oncol, Lhospitalet De Llobregat, Spain

[26] Univ Oviedo, Oviedo, Spain

[27] Publ Hlth Directorate Asturias, Oviedo, Spain

[28] Hlth Dept Basque Reg, BioDonostia Res Inst, Publ Hlth Div Gipuzkoa, San Sebastian, Spain

[29] Univ Oxford, Nuffield Dept Clin Med, Canc Epidemiol Unit, Oxford, England

[30] Univ Cambridge, Sch Clin Med, Cambridge, England

[31] Hellen Hlth Fdn, Athens, Greece

[32] Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, WHO Collaborating Ctr Food & Nutr Policies, Athens, Greece

[33] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA USA

[34] Acad Athens, Bureau Epidemiol Res, Athens, Greece

[35] German Inst Human Nutr Potsdam Rehbrucke, Dept Epidemiol, Nuthetal, Germany

[36] German Canc Res Ctr, Heidelberg, Germany

[37] Umea Univ, Nutr Res Mol Periodontol, Umea, Sweden

来源：

SCIENTIFIC REPORTS | 2016年 / 6卷

基金：

英国医学研究理事会;

关键词：

25-HYDROXYVITAMIN D; IN-VITRO; COLORECTAL-CANCER; RISK; ASSOCIATION; CARCINOGENESIS; ANGIOGENESIS; POPULATIONS; PLASMA;

D O I：

10.1038/srep36017

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Experimental and epidemiological data suggest that vitamin D play a role in pathogenesis and progression of cancer, but prospective data on head and neck cancer (HNC) and oesophagus cancer are limited. The European Prospective Investigation into Cancer and Nutrition (EPIC) study recruited 385,747 participants with blood samples between 1992 and 2000. This analysis includes 497 case-control pairs of the head and neck and oesophagus, as well as 443 additional controls. Circulating 25(OH)D-3 were measured in pre-diagnostic samples and evaluated in relation to HNC and oesophagus cancer risk and post-diagnosis all-cause mortality. After controlling for risk factors, a doubling of 25(OH)D-3 was associated with 30% lower odds of HNC (OR 0.70, 95% confidence interval [95% CI] 0.56-0.88, P-trend = 0.001). Subsequent analyses by anatomical sub-site indicated clear inverse associations with risk of larynx and hypopharynx cancer combined (OR 0.55, 95CI% 0.39-0.78) and oral cavity cancer (OR 0.60, 95CI% 0.42-0.87). Low 25(OH)D-3 concentrations were also associated with higher risk of death from any cause among HNC cases. No clear association was seen with risk or survival for oesophageal cancer. Study participants with elevated circulating concentrations of 25(OH)D-3 had decreased risk of HNC, as well as improved survival following diagnosis.

引用

页数：11

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