Functionalization of 2-bromo-N-benzyl indole via lithium-bromide exchange

被引：3
作者：
Feldman, Ken S. [1 ]
Gonzalez, Inanllely Y. [1 ]
Brown, Jocelyn E. [1 ]
机构：
[1] Penn State Univ, Dept Chem, University Pk, PA 16802 USA
来源：
TETRAHEDRON LETTERS | 2015年 / 56卷 / 23期
基金：
美国国家科学基金会;
关键词：
N-Benzyl indole; Lithium-bromide exchange; Nucleophilic addition; n-BuLi; ALKENES;
D O I：
10.1016/j.tetlet.2015.01.032
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The carbofunctionalization of 2-bromo-N-benzyl indole via lithium-bromide exchange is presented. The reaction scope is demonstrated by providing a variety of substrate examples that deliver carbofunctionalized products in good-to-excellent yields. The competition between nucleophilic addition and proton transfer is discussed. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3564 / 3566
页数：3
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