New efficient approach for the synthesis of 2-alkyl(aryl) substituted 4H-pyrido[1,2-a]pyrimidin-4-ones

被引：20

作者：

Bonacorso, HG ^{[1
]}

Righi, FJ ^{[1
]}

Rodrigues, IR ^{[1
]}

Cechinel, CA ^{[1
]}

Costa, MB ^{[1
]}

Wastowski, AD ^{[1
]}

Martins, MAP ^{[1
]}

Zanatta, N ^{[1
]}

机构：

[1] Univ Fed Santa Maria, Dept Quim, NUQUIMHE, BR-97105900 Santa Maria, RS, Brazil

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2006年 / 43卷 / 01期

关键词：

D O I：

10.1002/jhet.5570430136

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new, efficient and easy route for the preparation of a series of 2-alkyl(aryl) substituted 4-oxo-4H-pyrido[1,2-a]pyrimidines, where alkyl = CH3; aryl = C6H5,4-FC6H4,4-ClC6H4,4-BrC6H4, 4-CH3C6H4, 4-OCH3- C6H4, 4-NO2C6H4 in 45 - 80 % yield from the reaction of beta-alkoxyvinyl trichloromethyl ketones with 2-aminopyridine under mild conditions, is then reported.

引用

页码：229 / 233

页数：5

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