Human T-cell leukemia virus type 1 infection worsens prognosis of hepatitis C virus-related living donor liver transplantation

被引:7
作者
Ichikawa, Tatsuki [1 ]
Taura, Naota [1 ]
Miyaaki, Hisamitsu [1 ]
Matsuzaki, Toshihisa [1 ]
Ohtani, Masashi [1 ]
Eguchi, Susumu [2 ]
Takatsuki, Mitsuhisa [2 ]
Soyama, Akihisa [2 ]
Hidaka, Masaaki [2 ]
Okudaira, Sadayuki [2 ]
Usui, Tetsuya [4 ]
Mori, Sayaka [4 ]
Kamihira, Shimeru [3 ,4 ]
Kanematsu, Takashi [2 ]
Nakao, Kazuhiko [1 ]
机构
[1] Nagasaki Univ, Dept Gastroenterol & Hepatol, Grad Sch Biomed Sci, Nagasaki 8528501, Japan
[2] Nagasaki Univ, Dept Transplantat & Digest Surg, Grad Sch Biomed Sci, Nagasaki 8528501, Japan
[3] Nagasaki Univ, Dept Lab Med, Grad Sch Biomed Sci, Nagasaki 8528501, Japan
[4] Nagasaki Univ Hosp, Cent Diagnost Lab, Nagasaki, Japan
关键词
donor age; HCV; HTLV-1; liver transplantation; I-ASSOCIATED MYELOPATHY; RIBAVIRIN THERAPY; INTERFERON; IL28B; PREVALENCE; HTLV-1; RISK; CYCLOSPORINE; TACROLIMUS; RECIPIENTS;
D O I
10.1111/j.1432-2277.2012.01434.x
中图分类号
R61 [外科手术学];
学科分类号
摘要
Severe and life-threatening donor-transmitted human T-cell leukemia virus type 1 (HTLV-1) infections after solid organ transplantation have been reported. However, in HTLV-1-infected recipients, graft and patient survival were not fully evaluated. A total of 140 patients underwent living donor liver transplantation (LDLT). Of these, 47 of 126 adult recipients showed indications of hepatitis C virus (HCV)-related liver disease. The HTLV-1 prevalence rate was 10 of 140 recipients (7.14%) and three of 140 donors (0.02%). In HCV-related LDLT, graft and patient survival was worsened by HTLV-1 infection in recipients (seven cases). The 1-, 3-, and 5-year survival rates in the HCV/HTLV-1-co-infected group were 67%, 32%, and 15%, respectively, and the corresponding rates in the HCV-mono-infected group were 80%, 67%, and 67%, respectively. Only the 5-year survival rates were statistically significant (P = 0.04, log-rank method). HTLV-1 infection in recipients is also an important factor in predicting survival in HTLV-1 endemic areas.
引用
收藏
页码:433 / 438
页数:6
相关论文
共 33 条
[1]   A follow-up study of morbidity and mortality associated with hepatitis C virus infection and its interaction with human T lymphotropic virus type I in Miyazaki, Japan [J].
Boschi-Pinto, C ;
Stuver, S ;
Okayama, A ;
Trichopoulos, D ;
Orav, EJ ;
Tsubouchi, H ;
Mueller, N .
JOURNAL OF INFECTIOUS DISEASES, 2000, 181 (01) :35-41
[2]   Possible mechanism for positive interaction of human T cell leukemia type I on liver disease in a hepatitis C virus-infected Japanese cohort [J].
Casseb, J .
JOURNAL OF INFECTIOUS DISEASES, 2000, 182 (01) :379-379
[3]   Interleukin-28B Polymorphisms Are Associated With Histological Recurrence and Treatment Response Following Liver Transplantation in Patients With Hepatitis C Virus Infection [J].
Charlton, Michael R. ;
Thompson, Alexander ;
Veldt, Bart J. ;
Watt, Kym ;
Tillmann, Hans ;
Poterucha, John J. ;
Heimbach, Julie K. ;
Goldstein, David ;
McHutchison, John .
HEPATOLOGY, 2011, 53 (01) :317-324
[4]  
Eguchi S, 2007, ANN TRANSPL, V12, P11
[5]   Human T-cell leukemia virus type 1 blunts signaling by interferon alpha [J].
Feng, Xuan ;
Ratner, Lee .
VIROLOGY, 2008, 374 (01) :210-216
[6]   Incidence, Risk Factors, and Outcome of Chronic Rejection During Antiviral Therapy for Posttransplant Recurrent Hepatitis C [J].
Fernandez, Inmaculada ;
Ulloa, Esperanza ;
Colina, Francisco ;
Abradelo, Manuel ;
Jimenez, Carlos ;
Gimeno, Alberto ;
Carlos Meneu, Juan ;
Lumbreras, Carlos ;
Antonio Solis-Herruzo, Jose ;
Moreno, Enrique .
LIVER TRANSPLANTATION, 2009, 15 (08) :948-955
[7]   Variants in IL28B in Liver Recipients and Donors Correlate With Response to Peg-Interferon and Ribavirin Therapy for Recurrent Hepatitis C [J].
Fukuhara, Takasuke ;
Taketomi, Akinobu ;
Motomura, Takashi ;
Okano, Shinji ;
Ninomiya, Akinori ;
Abe, Takayuki ;
Uchiyama, Hideaki ;
Soejima, Yuji ;
Shirabe, Ken ;
Matsuura, Yoshiharu ;
Maehara, Yoshihiko .
GASTROENTEROLOGY, 2010, 139 (05) :1577-+
[8]  
Gessain A, 2000, PRESSE MED, V29, P2233
[9]   Epidemiology, Treatment, and Prevention of Human T-Cell Leukemia Virus Type 1-Associated Diseases [J].
Goncalves, Denise Utsch ;
Proietti, Fernando Augusto ;
Ramos Ribas, Joao Gabriel ;
Araujo, Marcelo Grossi ;
Pinheiro, Sonia Regina ;
Guedes, Antonio Carlos ;
Carneiro-Proietti, Anna Barbara F. .
CLINICAL MICROBIOLOGY REVIEWS, 2010, 23 (03) :577-+
[10]  
Hino Shigeo, 1997, Leukemia (Basingstoke), V11, P57