Human T-cell leukemia virus type 1 infection worsens prognosis of hepatitis C virus-related living donor liver transplantation

被引：7

作者：

Ichikawa, Tatsuki ^{[1
]}

Taura, Naota ^{[1
]}

Miyaaki, Hisamitsu ^{[1
]}

Matsuzaki, Toshihisa ^{[1
]}

Ohtani, Masashi ^{[1
]}

Eguchi, Susumu ^{[2
]}

Takatsuki, Mitsuhisa ^{[2
]}

Soyama, Akihisa ^{[2
]}

Hidaka, Masaaki ^{[2
]}

Okudaira, Sadayuki ^{[2
]}

Usui, Tetsuya ^{[4
]}

Mori, Sayaka ^{[4
]}

Kamihira, Shimeru ^{[3
,4
]}

Kanematsu, Takashi ^{[2
]}

Nakao, Kazuhiko ^{[1
]}

机构：

[1] Nagasaki Univ, Dept Gastroenterol & Hepatol, Grad Sch Biomed Sci, Nagasaki 8528501, Japan

[2] Nagasaki Univ, Dept Transplantat & Digest Surg, Grad Sch Biomed Sci, Nagasaki 8528501, Japan

[3] Nagasaki Univ, Dept Lab Med, Grad Sch Biomed Sci, Nagasaki 8528501, Japan

[4] Nagasaki Univ Hosp, Cent Diagnost Lab, Nagasaki, Japan

来源：

TRANSPLANT INTERNATIONAL | 2012年 / 25卷 / 04期

关键词：

donor age; HCV; HTLV-1; liver transplantation; I-ASSOCIATED MYELOPATHY; RIBAVIRIN THERAPY; INTERFERON; IL28B; PREVALENCE; HTLV-1; RISK; CYCLOSPORINE; TACROLIMUS; RECIPIENTS;

D O I：

10.1111/j.1432-2277.2012.01434.x

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Severe and life-threatening donor-transmitted human T-cell leukemia virus type 1 (HTLV-1) infections after solid organ transplantation have been reported. However, in HTLV-1-infected recipients, graft and patient survival were not fully evaluated. A total of 140 patients underwent living donor liver transplantation (LDLT). Of these, 47 of 126 adult recipients showed indications of hepatitis C virus (HCV)-related liver disease. The HTLV-1 prevalence rate was 10 of 140 recipients (7.14%) and three of 140 donors (0.02%). In HCV-related LDLT, graft and patient survival was worsened by HTLV-1 infection in recipients (seven cases). The 1-, 3-, and 5-year survival rates in the HCV/HTLV-1-co-infected group were 67%, 32%, and 15%, respectively, and the corresponding rates in the HCV-mono-infected group were 80%, 67%, and 67%, respectively. Only the 5-year survival rates were statistically significant (P = 0.04, log-rank method). HTLV-1 infection in recipients is also an important factor in predicting survival in HTLV-1 endemic areas.

引用

页码：433 / 438

页数：6

共 33 条

[1] A follow-up study of morbidity and mortality associated with hepatitis C virus infection and its interaction with human T lymphotropic virus type I in Miyazaki, Japan [J].