Modulation of Neocortical Development by Early Neuronal Activity: Physiology and Pathophysiology

被引:56
作者
Kirischuk, Sergei [1 ]
Sinning, Anne [1 ]
Blanquie, Oriane [1 ,2 ]
Yang, Jenq-Wei [1 ]
Luhmann, Heiko J. [1 ]
Kilb, Werner [1 ]
机构
[1] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Inst Physiol, Mainz, Germany
[2] German Ctr Neurodegenerat Dis DZNE, Bonn, Germany
关键词
development; cerebral cortex; subplate; spontaneous activity; somatosensory cortex; rodent; human; review; CAJAL-RETZIUS CELLS; ACTIVITY-DEPENDENT REGULATION; SUBUNIT MESSENGER-RNAS; CENTRAL-NERVOUS-SYSTEM; EARLY MOTOR-ACTIVITY; RAT VISUAL-CORTEX; CEREBRAL-CORTEX; NEONATAL SEIZURES; NMDA RECEPTORS; SPINDLE BURSTS;
D O I
10.3389/fncel.2017.00379
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Animal and human studies revealed that patterned neuronal activity is an inherent feature of developing nervous systems. This review summarizes our current knowledge about the mechanisms generating early electrical activity patterns and their impact on structural and functional development of the cerebral cortex. All neocortical areas display distinct spontaneous and sensory-driven neuronal activity patterns already at early phases of development. At embryonic stages, intermittent spontaneous activity is synchronized within small neuronal networks, becoming more complex with further development. This transition is accompanied by a gradual shift from electrical to chemical synaptic transmission, with a particular role of non-synaptic tonic currents before the onset of phasic synaptic activity. In this review article we first describe functional impacts of classical neurotransmitters (GABA, glutamate) and modulatory systems (e.g., acetylcholine, ACh) on early neuronal activities in the neocortex with special emphasis on electrical synapses, nonsynaptic and synaptic currents. Early neuronal activity influences probably all developmental processes and is crucial for the proper formation of neuronal circuits. In the second part of our review, we illustrate how specific activity patterns might interfere with distinct neurodevelopmental processes like proliferation, migration, axonal and dendritic sprouting, synapse formation and neurotransmitter specification. Finally, we present evidence that transient alterations in neuronal activity during restricted perinatal periods can lead to persistent changes in functional connectivity and therefore might underlie the manifestation of neurological and neuropsychiatric diseases.
引用
收藏
页数:21
相关论文
共 263 条
[1]   Role of emergent neural activity in visual map development [J].
Ackman, James B. ;
Crair, Michael C. .
CURRENT OPINION IN NEUROBIOLOGY, 2014, 24 :166-175
[2]   Oxygen and glucose deprivation induces major dysfunction in the somatosensory cortex of the newborn rat [J].
Albrecht, J ;
Hanganu, IL ;
Heck, N ;
Luhmann, HJ .
EUROPEAN JOURNAL OF NEUROSCIENCE, 2005, 22 (09) :2295-2305
[3]   Sequential Generation of Two Distinct Synapse-Driven Network Patterns in Developing Neocortex [J].
Allene, Camille ;
Cattani, Adriano ;
Ackman, James B. ;
Bonifazi, Paolo ;
Aniksztejn, Laurent ;
Ben-Ari, Yehezkel ;
Cossart, Rosa .
JOURNAL OF NEUROSCIENCE, 2008, 28 (48) :12851-12863
[4]   Sensory-Evoked and Spontaneous Gamma and Spindle Bursts in Neonatal Rat Motor Cortex [J].
An, Shuming ;
Kilb, Werner ;
Luhmann, Heiko J. .
JOURNAL OF NEUROSCIENCE, 2014, 34 (33) :10870-10883
[5]   Glycine receptors control the generation of projection neurons in the developing cerebral cortex [J].
Avila, A. ;
Vidal, P. M. ;
Tielens, S. ;
Morelli, G. ;
Laguesse, S. ;
Harvey, R. J. ;
Rigo, J-M ;
Nguyen, L. .
CELL DEATH AND DIFFERENTIATION, 2014, 21 (11) :1696-1708
[6]   Glycine receptors and brain development [J].
Avila, Ariel ;
Laurent Nguyen ;
Rigo, Jean-Michel .
FRONTIERS IN CELLULAR NEUROSCIENCE, 2013, 7
[7]   N-Methyl D-Aspartate Receptor Expression Patterns in the Human Fetal Cerebral Cortex [J].
Bagasrawala, Inseyah ;
Memi, Fani ;
Radonjic, Nevena V. ;
Zecevic, Nada .
CEREBRAL CORTEX, 2017, 27 (11) :5041-5053
[8]   Ketamine Enhances Human Neural Stem Cell Proliferation and Induces Neuronal Apoptosis via Reactive Oxygen Species-Mediated Mitochondrial Pathway [J].
Bai, Xiaowen ;
Yan, Yasheng ;
Canfield, Scott ;
Muravyeva, Maria Y. ;
Kikuchi, Chika ;
Zaja, Ivan ;
Corbett, John A. ;
Bosnjak, Zeljko J. .
ANESTHESIA AND ANALGESIA, 2013, 116 (04) :869-880
[9]   Organization of myelin in the mouse somatosensory barrel cortex and the effects of sensory deprivation [J].
Barrera, Kyrstle ;
Chu, Philip ;
Abramowitz, Jason ;
Steger, Robert ;
Ramos, Raddy L. ;
Brumberg, Joshua C. .
DEVELOPMENTAL NEUROBIOLOGY, 2013, 73 (04) :297-314
[10]   EXPRESSION OF INHIBITORY GLYCINE RECEPTORS IN POSTNATAL RAT CEREBRAL-CORTEX [J].
BECKER, CM ;
BETZ, H ;
SCHRODER, H .
BRAIN RESEARCH, 1993, 606 (02) :220-226