RNA N6-methyladenosine methylation in post-transcriptional gene expression regulation

被引:793
作者
Yue, Yanan [1 ,2 ]
Liu, Jianzhao [1 ,2 ]
He, Chuan [1 ,2 ]
机构
[1] Univ Chicago, Dept Chem, Inst Biophys Dynam, Chicago, IL 60637 USA
[2] Univ Chicago, Howard Hughes Med Inst, Chicago, IL 60637 USA
基金
美国国家卫生研究院;
关键词
N-6-methyladenosine; m(6)A methyltransferase; RNA demethylase; METTL3-METTL14; mRNA methylation; post-transcriptional regulation; ARABIDOPSIS MESSENGER-RNA; NUCLEAR-RNA; M(6)A RNA; FTO GENE; DNA METHYLATION; TET PROTEINS; N-6-ADENOSINE METHYLATION; MEDIATED FORMATION; MAPPING REVEALS; START SITES;
D O I
10.1101/gad.262766.115
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
N-6-methyladenosine (m(6)A) is the most prevalent and internal modification that occurs in the messenger RNAs (mRNA) of most eukaryotes, although its functional relevance remained a mystery for decades. This modification is installed by the m(6)A methylation "writers" and can be reversed by demethylases that serve as "erasers." In this review, we mainly summarize recent progress in the study of the m(6)A mRNA methylation machineries across eukaryotes and discuss their newly uncovered biological functions. The broad roles of m(6)A in regulating cell fates and embryonic development highlight the existence of another layer of epigenetic regulation at the RNA level, where mRNA is subjected to chemical modifications that affect protein expression.
引用
收藏
页码:1343 / 1355
页数:13
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