A single centre's experience of stereotactic radiosurgery and radiotherapy for non-functioning pituitary adenomas with the Linear Accelerator (Linac)

被引：35
作者：
Wilson, P. J. [2 ]
De-loyde, K. J. [1 ]
Williams, J. R. [1 ]
Smee, R. I. [1 ]
机构：
[1] Prince Wales Canc Ctr, Dept Radiat Oncol, Randwick, NSW 2031, Australia
[2] Wollongong Hosp, Dept Neurosurg, Wollongong, NSW, Australia
来源：
JOURNAL OF CLINICAL NEUROSCIENCE | 2012年 / 19卷 / 03期
关键词：
Pituitary gland; Progression-free survival; Radiotherapy; Radiological progression; Stereotactic radiotherapy; TUMORS; MACROADENOMAS; MANAGEMENT;
D O I：
10.1016/j.jocn.2011.07.025
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Non-functioning pituitary adenomas are primarily a surgically managed pathology, but recurrence or regrowth is not uncommon. Previous large series have retrospectively validated the use of the Gamma Knife (GK) as an adjuvant treatment. To our knowledge, we present the largest case series to date with the Linear Accelerator (Linac) for the management of this pathology. In this study we review the clinical course of 118 patients, 51 of whom had stereotactic radiosurgery (SRS) and 67 who had fractionated stereotactic radiotherapy (FSRT); the discriminatory feature being proximity to the optic chiasm. For comparison purposes a population of 53 patients who had conventional radiotherapy (CRT) is included. The local control rates at 5 years for SRS, FRST and CRT were 100%, 93% and 87% respectively. Treatment-related morbidity was low. These data confirm that Linac SRS and FSRT are safe and effective for the treatment of non-functioning pituitary adenomas. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：370 / 374
页数：5
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