Antimalarial activity of macrocyclic trichothecenes isolated from the fungus Myrothecium verrucaria

被引：68

作者：

Isaka, M ^{[1
]}

Punya, J ^{[1
]}

Lertwerawat, Y ^{[1
]}

Tanticharoen, M ^{[1
]}

Thebtaranonth, Y ^{[1
]}

机构：

[1] Natl Ctr Genet Engn & Biotechnol BIOTEC, Bangkok 10400, Thailand

来源：

JOURNAL OF NATURAL PRODUCTS | 1999年 / 62卷 / 02期

关键词：

D O I：

10.1021/np980323x

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Bioassay-guided fractionation of an extract from the fungus Myrothecium verrucaria BCC 112 resulted in the first isolation of roridin E acetate (5) from nature together with four common macrocyclic trichothecene isomers (1-4). Trichothecenes 1-5, while known as mycotoxins, were evaluated for their high antimalarial activity.

引用

页码：329 / 331

页数：3

共 17 条

[11] TUMOR INHIBITORS .125. ISOLATION OF POTENT NEW ANTILEUKEMIC TRICHOTHECENES FROM BACCHARIS-MEGAPOTAMICA
KUPCHAN, SM
STREELMAN, DR
JARVIS, BB
DAILEY, RG
SNEDEN, AT
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1977, 42 (26) : 4221 - 4225
[12] TRADITIONAL MEDICINAL-PLANTS OF THAILAND .20. CYTOTOXIC AND ANTIMALARIAL BISBENZYLISOQUINOLINE ALKALOIDS FROM STEPHANIA-ERECTA
LIKHITWITAYAWUID, K
ANGERHOFER, CK
CORDELL, GA
PEZZUTO, JM
RUANGRUNGSI, N
[J]. JOURNAL OF NATURAL PRODUCTS, 1993, 56 (01): : 30 - 38
[13] MATSUMOTO M, 1977, TETRAHEDRON LETT, P4093
[14] Strong FM, 1971, MICROBIAL TOXINS, V7, P207
[15] Tamm C., 1974, FORTSCHR CHEM ORG NA, V31, P63
[16] TRAGER W, 1976, SCIENCE, V193, P673, DOI 10.1126/science.781840
[17] TRAXLER P, 1970, Helvetica Chimica Acta, V53, P2071, DOI 10.1002/hlca.19700530818

← 1 2 →