Antimalarial activity of macrocyclic trichothecenes isolated from the fungus Myrothecium verrucaria

被引：69

作者：

Isaka, M ^{[1
]}

Punya, J ^{[1
]}

Lertwerawat, Y ^{[1
]}

Tanticharoen, M ^{[1
]}

Thebtaranonth, Y ^{[1
]}

机构：

[1] Natl Ctr Genet Engn & Biotechnol BIOTEC, Bangkok 10400, Thailand

来源：

JOURNAL OF NATURAL PRODUCTS | 1999年 / 62卷 / 02期

关键词：

D O I：

10.1021/np980323x

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Bioassay-guided fractionation of an extract from the fungus Myrothecium verrucaria BCC 112 resulted in the first isolation of roridin E acetate (5) from nature together with four common macrocyclic trichothecene isomers (1-4). Trichothecenes 1-5, while known as mycotoxins, were evaluated for their high antimalarial activity.

引用

页码：329 / 331

页数：3

共 17 条

[1] UBER DIE ISOLIERUNG VON VERRUCARIN H VERRUCARIN J RORIDIN D UND RORIDIN E AUS MYROTHECIUM-ARTEN - VERRUCARINE UND RORIDINE .8. [J].

BOHNER, B ;

FETZ, E ;

HARRI, E ;

SIGG, HP ;

STOLL, C ;

TAMM, C .

HELVETICA CHIMICA ACTA, 1965, 48 (05) :1079-&

[2]

BOHRNER B, 1966, HELV CHIM ACTA, V49, P2527

[3]

COLE RJ, 1981, HDB TOXIC FUNGAL MET, P153

[4] QUANTITATIVE ASSESSMENT OF ANTI-MALARIAL ACTIVITY INVITRO BY A SEMIAUTOMATED MICRODILUTION TECHNIQUE [J].

DESJARDINS, RE ;

CANFIELD, CJ ;

HAYNES, JD ;

CHULAY, JD .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1979, 16 (06) :710-718

[5] MACROCYCLIC TRICHOTHECENES [J].

GROVE, JF .

NATURAL PRODUCT REPORTS, 1993, 10 (05) :429-448

[6]

GUTZWILLER J, 1965, HELV CHIM ACTA, V48, P157, DOI 10.1002/hlca.19650480117

[7] UBER DIE VERRUCARINE UND RORIDINE, EINE GRUPPE VON CYTOSTATISCH HOCHWIRKSAMEN ANTIBIOTICA AUS MYROTHECIUM-ARTEN [J].

HARRI, E ;

STOLL, C ;

SIGG, HP ;

LOEFFLER, W ;

STAHELIN, H ;

TAMM, C ;

WIESINGER, D .

HELVETICA CHIMICA ACTA, 1962, 45 (03) :839-+

[8] ANTI-LEUKEMIC COMPOUNDS DERIVED FROM THE CHEMICAL MODIFICATION OF MACROCYCLIC TRICHOTHECENES .1. DERIVATIVES OF VERRUCARIN-A [J].

JARVIS, BB ;

STAHLY, GP ;

PAVANASASIVAM, G ;

MAZZOLA, EP .

JOURNAL OF MEDICINAL CHEMISTRY, 1980, 23 (09) :1054-1058

[9] ISOLATION AND CHARACTERIZATION OF THE TRICHOVERROIDS AND NEW RORIDINS AND VERRUCARINS [J].

JARVIS, BB ;

STAHLY, GP ;

PAVANASASIVAM, G ;

MIDIWO, JO ;

DESILVA, T ;

HOLMLUND, CE ;

MAZZOLA, EP ;

GEOGHEGAN, RF .

JOURNAL OF ORGANIC CHEMISTRY, 1982, 47 (06) :1117-1124

[10] STEREOCHEMISTRY OF THE RORIDINS [J].

JARVIS, BB ;

MIDIWO, JO ;

FLIPPENANDERSON, JL ;

MAZZOLA, EP .

JOURNAL OF NATURAL PRODUCTS, 1982, 45 (04) :440-448

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