Antimalarial activity of macrocyclic trichothecenes isolated from the fungus Myrothecium verrucaria

被引：68

作者：

Isaka, M ^{[1
]}

Punya, J ^{[1
]}

Lertwerawat, Y ^{[1
]}

Tanticharoen, M ^{[1
]}

Thebtaranonth, Y ^{[1
]}

机构：

[1] Natl Ctr Genet Engn & Biotechnol BIOTEC, Bangkok 10400, Thailand

来源：

JOURNAL OF NATURAL PRODUCTS | 1999年 / 62卷 / 02期

关键词：

D O I：

10.1021/np980323x

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Bioassay-guided fractionation of an extract from the fungus Myrothecium verrucaria BCC 112 resulted in the first isolation of roridin E acetate (5) from nature together with four common macrocyclic trichothecene isomers (1-4). Trichothecenes 1-5, while known as mycotoxins, were evaluated for their high antimalarial activity.

引用

页码：329 / 331

页数：3

共 17 条

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