Synthesis, in vitro antibacterial and carbonic anhydrase II inhibitory activities of N-acylsulfonamides using silica sulfuric acid as an efficient catalyst under both solvent-free and heterogeneous conditions

被引：49

作者：

Massah, Ahmad Reza ^{[1
]}

Adibi, Hadi ^{[2
]}

Khodarahmi, Reza ^{[3
,4
]}

Abiri, Ramin ^{[5
]}

Majnooni, Mohammad Bagher ^{[2
]}

Shahidi, Sherita ^{[1
]}

Asadi, Beheshteh ^{[1
]}

Mehrabi, Masomeh ^{[2
]}

Zolfigol, Mohammad Ali ^{[6
]}

机构：

[1] Islamic Azad Univ, Dept Chem, Shahreza Branch, Shahreza 86145311, Iran

[2] Kermanshah Univ Med Sci, Dept Med Chem, Fac Pharm, Kermanshah 671451673, Iran

[3] Kermanshah Univ Med Sci, Dept Pharmacognosy & Biotechnol, Fac Pharm, Kermanshah 671451673, Iran

[4] Kermanshah Univ Med Sci, Med Biol Res Ctr, Kermanshah 671451673, Iran

[5] Kermanshah Univ Med Sci, Fac Med, Dept Microbiol, Kermanshah 671451673, Iran

[6] Bu Ali Sina Univ, Fac Chem, Hamadan 65174, Iran

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2008年 / 16卷 / 10期

关键词：

N-acylsulfonamides; silica sulfuric acid; solvent-free; antibacterial activity; carbonic anhydrase II inhibitor;

D O I：

10.1016/j.bmc.2008.04.011

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Silica sulfuric acid catalyzes efficiently the reaction of sulfonamides with both carboxylic acid anhydrides and chlorides under solvent-free and heterogeneous conditions. All the reactions were done at room temperature and the N-acylsulfonamides were obtained with high yields and purity via an easy work-up procedure. This method is attractive and is in a close agreement with green chemistry. These compounds were also investigated for antibacterial activity, including Gram-positive cocci and Gram-negative bacilli, and carbonic anhydrase II inhibitory activity. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：5465 / 5472

页数：8

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