The role of antigen-presenting cells in the pathogenesis of COVID-19

被引：16

作者：

Farzi, Rana ^{[1
,2
]}

Aghbash, Parisa Shiri ^{[1
,2
]}

Eslami, Narges ^{[2
,3
]}

Azadi, Arezou ^{[1
,2
,5
]}

Shamekh, Ali ^{[2
,4
]}

Hemmat, Nima ^{[1
,3
]}

Entezari-Maleki, Taher ^{[6
,7
]}

Baghi, Hossein Bannazadeh ^{[1
,2
,5
]}

机构：

[1] Tabriz Univ Med Sci, Immunol Res Ctr, Tabriz, Iran

[2] Tabriz Univ Med Sci, Infect & Trop Dis Res Ctr, Tabriz 516615731, Iran

[3] Tabriz Univ Med Sci, Drug Appl Res Ctr, Tabriz, Iran

[4] Tabriz Univ Med Sci, Student Res Comm, Tabriz, Iran

[5] Tabriz Univ Med Sci, Fac Med, Dept Virol, Tabriz, Iran

[6] Tabriz Univ Med Sci, Fac Pharm, Dept Clin Pharm, Tabriz, Iran

[7] Tabriz Univ Med Sci, Cardiovasc Res Ctr, Tabriz, Iran

来源：

PATHOLOGY RESEARCH AND PRACTICE | 2022年 / 233卷

关键词：

Antigen Presenting Cell; B cells; COVID-19; DC; Macrophages; SARS-CoV-2; RESPIRATORY SYNDROME CORONAVIRUS; PLASMACYTOID DENDRITIC CELLS; INFLUENZA-VIRUS; B-CELLS; INFECTION; MACROPHAGES; SPIKE; REPLICATION; ACTIVATION; INDUCTION;

D O I：

10.1016/j.prp.2022.153848

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Coronavirus Disease 2019 (COVID-19) is one of the three lethal coronavirus outbreaks in the recent two decades and a serious threat to global health all over the world. The principal feature of the COVID-19 infection is the socalled "cytokine storm" exaggerated molecular response to virus distribution, which plays massive tissue and organ injury roles. Immunological treatments, including monoclonal antibodies and vaccines, have been suggested as the main approaches in treating and preventing this disease. Therefore, a proper investigation of the roles of antigen-presenting cells (APCs) in the aforementioned immunological responses appears essential. The present review will provide detailed information about APCs' role in the infection and pathogenesis of SARSCoV-2 and the effect of monoclonal antibodies in diagnosis and treatment.

引用

页数：12

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