N-aryl sulfonyl homocysteine hydroxamate inhibitors of matrix metalloproteinases:: further probing of the S1, S1′, and S2′ pockets

被引：44

作者：

Hanessian, S ^{[1
]}

Moitessier, N ^{[1
]}

Gauchet, C ^{[1
]}

Viau, M ^{[1
]}

机构：

[1] Univ Montreal, Dept Chem, Montreal, PQ H3C 3J7, Canada

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2001年 / 44卷 / 19期

关键词：

D O I：

10.1021/jm010097f

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of N-arylsulfonyl S-alkyl homocysteine hydroxamic acids were synthesized with variations in three subsites corresponding to P-1, P-1', and P-2'. Enzyme assays with a variety of MMPs revealed activity at the low nanomolar level.

引用

页码：3066 / 3073

页数：8

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