Palladium-Catalyzed Enantioselective CH Arylation for the Synthesis of P-Stereogenic Compounds

被引：160
作者：
Lin, Zi-Qi [1 ]
Wang, Wei-Zhen [1 ]
Yan, Shao-Bai [1 ]
Duan, Wei-Liang [1 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2015年 / 54卷 / 21期
关键词：
asymmetric catalysis; CH activation; chirality; palladium; Pligands; H BOND ACTIVATION; PLANAR CHIRAL FERROCENES; ASYMMETRIC-SYNTHESIS; QUATERNARY STEREOCENTERS; PHOSPHORUS-COMPOUNDS; PRACTICAL SYNTHESIS; PHOSPHINE-LIGANDS; CARBOXYLIC ESTERS; SULFONIC ESTERS; RHODIUM COMPLEX;
D O I：
10.1002/anie.201500201
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A palladium-catalyzed enantioselective CH arylation of N-(o-bromoaryl)-diarylphosphinic amides is described for the synthesis of phosphorus compounds bearing a P-stereogenic center. The method provides good enantioselectivities and high yields. The products were readily transformed into P-chiral biphenyl monophosphine ligands.
引用
收藏
页码：6265 / 6269
页数：5
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