Polystyrene-Supported Triphenylsilyl Chloride for the Silylation-Based Kinetic Resolution of Secondary Alcohols

被引：13

作者：

Akhani, Ravish K. ^{[1
]}

Clark, Robert W. ^{[1
]}

Yuan, Liang ^{[1
]}

Wang, Li ^{[1
]}

Tang, Chuanbing ^{[1
]}

Wiskur, Sheryl L. ^{[1
]}

机构：

[1] Univ S Carolina, Dept Chem & Biochem, Columbia, SC 29208 USA

来源：

CHEMCATCHEM | 2015年 / 7卷 / 10期

基金：

美国国家科学基金会;

关键词：

chirality; kinetic resolution; polymers; polymer supports; silylation; SILICON-STEREOGENIC SILANES; CATALYTIC ENANTIOSELECTIVE SILYLATION; ZIRCONOCENE POLYMERIZATION CATALYSTS; DONOR-FUNCTIONALIZED ALCOHOLS; CHIRAL ALPHA-OLEFINS; POLY(ETHYLENE GLYCOL); ENZYMATIC-HYDROLYSIS; EASY SEPARATION; ORGANIC MEDIA; ACYL TRANSFER;

D O I：

10.1002/cctc.201500173

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A silyl chloride derivatized styrene polymer was employed in the silylation-based kinetic resolution of secondary alcohols for chromatography-free separation of alcohol enantiomers. Synthetically useful selectivity factors were obtained; furthermore, the polymer was recycled for use in a subsequent kinetic resolution, and it maintained its selectivity and integrity.

引用

页码：1527 / 1530

页数：4

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