Pharmacological treatment after acute coronary syndrome: Baseline clinical characteristics and gender differences in a population-based cohort study

Objective: To describe baseline socio-demographic and clinical characteristics and drugs prscribed for secondary prevention after a first episode of ACS and to assess differences between men and women. Setting: PHC in Catalonia. Data source: SIDIAP (Information System for Research in Primary Care). Participants: Patients who suffered an ACS during 2009-2016 and followed-up in PHC centres of the Catalan Health Institute in Catalonia. Main measures: Socio-demographic and clinical characteristics at baseline: sex, age, socioeconomic index, toxic habits, comorbidities, study drugs (prescribed for cardiovascular secondary prevention: antiplatelets, betablockers, statins, drugs acting on the renin-angiotensin system) and comedications. Results: 8071 patients included, 71.3% of them were men and 80.2% had an acute myocardial infarction. Their mean age was 65.3 and women were older than men. The most frequent comorbidities were hypertension, dyslipidaemia and diabetes and they were more common in women. Antiplatelets (91.3%) and statins (85.7%) were the study drugs most prescribed. The uses of all comedications were significantly higher in women, except for nitrates. The combination of four study groups was initially prescribed in 47.7% of patients and combination of betablockers, statins and antiplatelets was prescribed in 18.4%. More men than women received all recommended pharmacological groups. Conclusion: Women were older, had more comorbidities and received more comedications. Most patients were treated with a combination of four or three study drugs for secondary prevention. Men initiated more drug treatments for secondary prevention and dual antiptatelet therapy than women. (C) 2021 The Author(s). Published by Elsevier Espana, S.L.U.