Neurochemical sensitization associated with systemic administration of tumor necrosis factor-α:: adjuvant action in combination with bovine serum albumin

被引：5

作者：

Anisman, H ^{[1
]}

Turrin, NP

Merali, Z

Hayley, S

机构：

[1] Carleton Univ, Inst Neurosci, Ottawa, ON K1S 5B6, Canada

[2] CHUL, Res Ctr, Mol Endocrinol Lab, Ste Foy, PQ, Canada

[3] Univ Ottawa, Cellular & Mol Med, Ottawa, ON K1N 6N5, Canada

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2003年 / 145卷 / 1-2期

基金：

加拿大健康研究院; 加拿大自然科学与工程研究理事会;

关键词：

tumor necrosis factor-alpha; bovine serum albumin; sensitization; corticosterone; norepinephrine; serotonin;

D O I：

10.1016/j.jneuroim.2003.09.014

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Tumor necrosis factor-alpha (TNF-alpha) provokes a time-dependent sensitization of brain monoamine activity, plasma corticosterone activity and sickness behavior, the latter being reminiscent of septic or anaphylactic shock. In this investigation, bovine serum albumin (BSA) elicited similar corticosterone and sickness profiles, whereas the monoamine changes were not observed. The sensitization elicited by mTNF-alpha plus BSA was markedly greater that that elicited by BSA alone. Carrier-free TNF-alpha promoted the sensitization of brain monoamine activity, but not sickness or corticosterone. It is suggested that mTNF-alpha acts as an adjuvant to the anaphylactic actions elicited by BSA, but may provoke a sensitization of monoamine activity which is time-dependent and varies across brain regions. (C) 2003 Elsevier B.V. All rights reserved.

引用

页码：91 / 102

页数：12

共 42 条

[1]

Allison AC, 1998, DEV BIOL STAND, V92, P3

[2] Cytokines, stress and depressive illness: brain-immune interactions [J].

Anisman, H ;

Merali, Z .

ANNALS OF MEDICINE, 2003, 35 (01) :2-11

[3] Sensitization associated with stressors and cytokine treatments [J].

Anisman, H ;

Merali, Z ;

Hayley, S .

BRAIN BEHAVIOR AND IMMUNITY, 2003, 17 (02) :86-93

[4] Psychogenic, neurogenic, and systemic stressor effects on plasma corticosterone and behavior: Mouse strain-dependent outcomes [J].

Anisman, H ;

Hayley, S ;

Kelly, O ;

Borowski, T ;

Merali, Z .

BEHAVIORAL NEUROSCIENCE, 2001, 115 (02) :443-454

[5]

Anisman H, 1999, ADV EXP MED BIOL, V461, P199

[6]

ANISMAN H, 1991, NEUROMETHODS, V19, P1

[7]

BARRON RL, 1993, CLIN PHARMACY, V12, P829

[8] Synergistic effects of interleukin-1β, interleukin-6, and tumor necrosis factor-α:: Central monoamine, corticosterone, and behavioral variations [J].

Brebner, K ;

Hayley, S ;

Zacharko, R ;

Merali, Z ;

Anisman, H .

NEUROPSYCHOPHARMACOLOGY, 2000, 22 (06) :566-580

[9] The physiology of brain histamine [J].

Brown, RE ;

Stevens, DR ;

Haas, HL .

PROGRESS IN NEUROBIOLOGY, 2001, 63 (06) :637-672

[10] Systemic administration of interleukin-1β activates select populations of central amygdala afferents [J].

Buller, KM ;

Day, TA .

JOURNAL OF COMPARATIVE NEUROLOGY, 2002, 452 (03) :288-296

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