Cerebrospinal fluid is a significant fluid source for anoxic cerebral oedema

被引：33

作者：

Du, Ting ^{[1
,2
]}

Mestre, Humberto ^{[1
,3
,4
]}

Kress, Benjamin T. ^{[1
,5
]}

Liu, Guojun ^{[1
,6
]}

Sweeney, Amanda M. ^{[1
]}

Samson, Andrew J. ^{[5
]}

Rasmussen, Martin Kaag ^{[5
]}

Mortensen, Kristian Nygaard ^{[5
]}

Bork, Peter A. R. ^{[5
,7
]}

Peng, Weiguo ^{[1
,5
]}

Olveda, Genaro E. ^{[1
]}

Bashford, Logan ^{[8
]}

Toro, Edna R. ^{[8
]}

Tithof, Jeffrey ^{[8
,9
]}

Kelley, Douglas H. ^{[8
]}

Thomas, John H. ^{[8
]}

Hjorth, Poul G. ^{[7
]}

Martens, Erik A. ^{[7
,10
]}

Mehta, Rupal, I ^{[1
,11
]}

Hirase, Hajime ^{[5
]}

Mori, Yuki ^{[5
]}

Nedergaard, Maiken ^{[1
,5
]}

机构：

[1] Univ Rochester, Ctr Translat Neuromed, Dept Neurosurg, Med Ctr, 601 Elmwood Ave,Box 645, Rochester, NY 14642 USA

[2] China Med Univ, Sch Pharm, Shenyang 110122, Peoples R China

[3] Univ Rochester, Dept Neurosci, Med Ctr, Rochester, NY 14642 USA

[4] Univ Penn, Dept Neurol, Philadelphia, PA 19104 USA

[5] Univ Copenhagen, Fac Hlth & Med Sci, Ctr Translat Neuromed, DK-2200 Copenhagen, Denmark

[6] China Med Univ, Affiliated Hosp 4, Dept Neurosurg, Shenyang 110032, Peoples R China

[7] Tech Univ Denmark, Dept Appl Math & Comp Sci, Richard Petersens Plads, DK-2800 Lyngby, Denmark

[8] Univ Rochester, Dept Mech Engn, Rochester, NY 14627 USA

[9] Univ Minnesota, Dept Mech Engn, Minneapolis, MN 55455 USA

[10] Lund Univ, Ctr Math Sci, S-22100 Lund, Sweden

[11] Rush Univ, Alzheimers Dis Ctr, Dept Pathol, Chicago, IL USA

来源：

BRAIN | 2022年 / 145卷 / 02期

基金：

美国国家卫生研究院;

关键词：

cerebrospinal fluid; cardiac arrest; anoxic cerebral oedema; spreading depolarizations; CELL; DEPOLARIZATION;

D O I：

10.1093/brain/awab293

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Cerebral oedema develops after anoxic brain injury. In two models of asphyxial and asystolic cardiac arrest without resuscitation, we found that oedema develops shortly after anoxia secondary to terminal depolarizations and the abnormal entry of CSF. Oedema severity correlated with the availability of CSF with the age-dependent increase in CSF volume worsening the severity of oedema. Oedema was identified primarily in brain regions bordering CSF compartments in mice and humans. The degree of ex vivo tissue swelling was predicted by an osmotic model suggesting that anoxic brain tissue possesses a high intrinsic osmotic potential. This osmotic process was temperature-dependent, proposing an additional mechanism for the beneficial effect of therapeutic hypothermia. These observations show that CSF is a primary source of oedema fluid in anoxic brain. This novel insight offers a mechanistic basis for the future development of alternative strategies to prevent cerebral oedema formation after cardiac arrest.

引用

页码：787 / 797

页数：11

共 31 条

[1]

Benjamin EJ., 2019, CIRCULATION, V139139, P56

[2] Delays in Cardiopulmonary Resuscitation, Defibrillation, and Epinephrine Administration All Decrease Survival in In-hospital Cardiac Arrest [J].

Bircher, Nicholas G. ;

Chan, Paul S. ;

Xu, Yan ;

Faillace, Robert T. ;

Mancini, Mary E. ;

Berg, Robert A. ;

Allen, Emilie ;

Hunt, Elizabeth A. ;

Nadkarni, Vinay M. ;

Peberdy, Mary Ann ;

Ornato, Joseph P. ;

Braithwaite, Scott ;

Nichol, Graham ;

Warren, Samuel ;

Duncan, Kathy ;

LaBresh, Kenneth ;

Sasson, Comilla ;

Knight, Lynda ;

Donnino, Michael W. ;

Smyth, Mindy ;

Eigel, Brian ;

Gent, Lana ;

Mader, Timothy J. ;

Kern, Karl B. ;

Geocadin, Romergryko G. .

ANESTHESIOLOGY, 2019, 130 (03) :414-422

[3] Temporal course of cerebrospinal fluid dynamics and amyloid accumulation in the aging rat brain from three to thirty months [J].

Chiu C. ;

Miller M.C. ;

Caralopoulos I.N. ;

Worden M.S. ;

Brinker T. ;

Gordon Z.N. ;

Johanson C.E. ;

Silverberg G.D. .

Fluids and Barriers of the CNS, 9 (1)

[4] A Biophysical Model for Cytotoxic Cell Swelling [J].

Dijkstra, Koen ;

Hofmeijer, Jeannette ;

van Gils, Stephan A. ;

van Putten, Michel J. A. M. .

JOURNAL OF NEUROSCIENCE, 2016, 36 (47) :11881-11890

[5] Spreading depolarization is not an epiphenomenon but the principal mechanism of the cytotoxic edema in various gray matter structures of the brain during stroke [J].

Dreier, Jens P. ;

Lemale, Coline L. ;

Kola, Vasilis ;

Friedman, Alon ;

Schoknecht, Karl .

NEUROPHARMACOLOGY, 2018, 134 :189-207

[6] Terminal spreading depolarization and electrical silence in death of human cerebral cortex [J].

Dreier, Jens P. ;

Major, Sebastian ;

Foreman, Brandon ;

Winkler, Maren K. L. ;

Kang, Eun-Jeung ;

Milakara, Denny ;

Lemale, Coline L. ;

DiNapoli, Vince ;

Hinzman, Jason M. ;

Woitzik, Johannes ;

Andaluz, Norberto ;

Carlson, Andrew ;

Hartings, Jed A. .

ANNALS OF NEUROLOGY, 2018, 83 (02) :295-310

[7] The Stroke-Migraine Depolarization Continuum [J].

Dreier, Jens P. ;

Reiffurth, Clemens .

NEURON, 2015, 86 (04) :902-922

[8] Biological sex does not predict glymphatic influx in healthy young, middle aged or old mice [J].

Giannetto, Michael ;

Xia, Maosheng ;

Staeger, Frederik Filip ;

Metcalfe, Tanner ;

Vinitsky, Hanna S. ;

Dang, Juliana A. M. L. ;

Xavier, Anna L. R. ;

Kress, Benjamin T. ;

Nedergaard, Maiken ;

Hablitz, Lauren M. .

SCIENTIFIC REPORTS, 2020, 10 (01)

[9] Cerebral Edema After Cardiopulmonary Resuscitation: A Therapeutic Target Following Cardiac Arrest? [J].

Hayman, Erik G. ;

Patel, Akil P. ;

Kimberly, W. Taylor ;

Sheth, Kevin N. ;

Simard, J. Marc .

NEUROCRITICAL CARE, 2018, 28 (03) :276-287

[10]

LEAF A., 1955, BIOCHEM JOUR, V60, pxl

← 1 2 3 4 →