DUSP13B/TMDP inhibits stress-activated MAPKs and suppresses AP-1-dependent gene expression

被引：11
|
作者：
Katagiri, Chiaki [1 ,2 ]
Masuda, Kouhei [1 ,2 ]
Nomura, Miyuki [1 ]
Tanoue, Kan [2 ]
Fujita, Shoko [2 ]
Yamashita, Yoji [1 ]
Katakura, Ryuichi [1 ]
Shiiba, Ken-ichi [1 ]
Nomura, Eiki [1 ]
Sato, Masami [1 ]
Tanuma, Nobuhiro [1 ,3 ]
Shima, Hiroshi [1 ,3 ]
机构：
[1] Miyagi Canc Ctr, Res Inst, Div Canc Chemotherapy, Natori, Miyagi 9811293, Japan
[2] Hokkaido Univ, Inst Med Genet, Div Biochem Oncol & Immunol, Sapporo, Hokkaido, Japan
[3] Tohoku Univ, Sch Med, Div Canc Mol Biol, Natori, Miyagi, Japan
来源：
MOLECULAR AND CELLULAR BIOCHEMISTRY | 2011年 / 352卷 / 1-2期
基金：
日本学术振兴会;
关键词：
Atypical dual-specificity phosphatase; DUSP13; TMDP; MAPK; AP-1; Spermatogenesis; SPECIFICITY PROTEIN PHOSPHATASE; SUBSTRATE-SPECIFICITY; CRYSTAL-STRUCTURE; JNK; VHR; KINASES; MKP-7; ERK; SPERMATOGENESIS; PHOSPHORYLATION;
D O I：
10.1007/s11010-011-0749-x
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The dual-specificity phosphatase (DUSP) 13 gene encodes two atypical DUSPs, DUSP13B/TMDP and DUSP13A/MDSP using alternative exons. DUSP13B protein is most highly expressed in testis, particularly in spermatocytes and round spermatids of the seminiferous tubules, while that of DUSP13A is restricted to skeletal muscle. Here, we show that DUSP13B inactivated MAPK activation in the order of selectivity, JNK = p38 > ERK in cells, while DUSP13A did not show MAPK phosphatase activity. Reporter gene analysis showed that DUSP13B had significant inhibitory effect on AP-1-dependent gene expression, but DUSP13A did not. To our knowledge, DUSP13B is the first identified testis-specific phosphatase that inhibits stress-activated MAPKs. These data suggest an important role for DUSP13B in protection from external stress during spermatogenesis.
引用
收藏
页码：155 / 162
页数：8
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