Centiloid scaling for quantification of brain amyloid with [18F]flutemetamol using multiple processing methods

被引：76

作者：

Battle, Mark R. ^{[1
]}

Pillay, Lovena Chedumbarum ^{[1
]}

Lowe, Val J. ^{[2
]}

Knopman, David ^{[2
]}

Kemp, Bradley ^{[2
]}

Rowe, Christopher C. ^{[3
]}

Dore, Vincent ^{[3
]}

Villemagne, Victor L. ^{[3
]}

Buckley, Christopher J. ^{[1
]}

机构：

[1] GE Healthcare, Imaging Technol Grp, Grove Ctr, White Lion Rd, Amersham, Bucks, England

[2] Mayo Clin, Rochester, MN USA

[3] Austin Hlth, Melbourne, Vic, Australia

来源：

EJNMMI RESEARCH | 2018年 / 8卷

基金：

美国国家卫生研究院;

关键词：

MILD COGNITIVE IMPAIRMENT; ALZHEIMERS-DISEASE; ROBUST; FLUTEMETAMOL; OPTIMIZATION; REGISTRATION; C-11-PIB;

D O I：

10.1186/s13550-018-0456-7

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Introduction: A standardised method for quantifying beta-amyloid PET tracers would allow comparison across different tracers and different sites. The development of the Centiloid scale has aimed to achieve this, applying a common scale to better aid the diagnosis and prognosis of Alzheimer's disease (AD) and to monitor anti-amyloid therapeutic interventions. Here, we apply the Centiloid method to [F-18]flutemetamol and [C-11]PiB (PiB, Pittsburgh compound B) PET images and derive the scaling factor to express their binding in Centiloids. Methods: Paired PiB and [F-18]flutemetamol scans for 74 subjects, including 24 young healthy controls (37 +/- 5 years), were analysed using the standard Centiloid method. The same subjects were also analysed using PMOD- and FSL-based pipelines as well as SPM8. Test-retest analysis of 10AD subjects was also performed with each pipeline. Results: The standard uptake value ratios (SUVR), determined using the standard SPM8 Centiloid process, showed a strong correlation between [F-18]flutemetamol (Flute) and PiB binding (SUVR-Flute=0.77 x SUVR-PiB+0.22, R-2=0.96). Application of the standard Centiloid process allowed the calculation of a direct conversion equation for SUVR-Flute to Centiloid units (CL) (CL=(121.42*SUVR-Flute) - 121.16). Analysis of the data via the two alternate Centiloid pipelines allowed us to derive standardised, SPM8-equivalent equations for both PMOD (CL= (115.24*SUVR-Flute) - 107.86) and FSL (CL= (120.32*SUVR-Flute) - 112.75) respectively. Test-retest analysis of 10AD subjects showed an approximate 2% difference for each pipeline. Conclusions: [F-18]flutemetamol data can now be expressed in Centiloid units, enhancing its utility in clinical and research applications for beta-amyloid imaging. The standard Centiloid method also demonstrates that [F-18]flutemetamol has favourable performance compared with PiB and other beta-amyloid tracers. Test-retest difference averaged 2%, with no difference between image processing pipelines. Centiloid scaling is robust and can be implemented on a number of platforms.

引用

页数：11

共 24 条

[21] The amyloid hypothesis of Alzheimer's disease at 25years [J].

Selkoe, Dennis J. ;

Hardy, John .

EMBO MOLECULAR MEDICINE, 2016, 8 (06) :595-608

[22] Fast robust automated brain extraction [J].

Smith, SM .

HUMAN BRAIN MAPPING, 2002, 17 (03) :143-155

[23]

Tudorascu Dana L, 2018, Alzheimers Dement (Amst), V10, P332, DOI 10.1016/j.dadm.2018.03.006

[24] 18F-Flutemetamol Amyloid Imaging in Alzheimer Disease and Mild Cognitive Impairment A Phase 2 Trial [J].

Vandenberghe, Rik ;

Van Laere, Koen ;

Ivanoiu, Adrian ;

Salmon, Eric ;

Bastin, Christine ;

Triau, Eric ;

Hasselbalch, Steen ;

Law, Ian ;

Andersen, Allan ;

Korner, Alex ;

Minthon, Lennart ;

Garraux, Gaetan ;

Nelissen, Natalie ;

Bormans, Guy ;

Buckley, Chris ;

Owenius, Rikard ;

Thurfjell, Lennart ;

Farrar, Gill ;

Brooks, David J. .

ANNALS OF NEUROLOGY, 2010, 68 (03) :319-329

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