Angiogenesis Markers Quantification in Breast Cancer and Their Correlation with Clinicopathological Prognostic Variables

被引：61

作者：

Rykala, Jan ^{[1
]}

Przybylowska, Karolina ^{[2
]}

Majsterek, Ireneusz ^{[2
]}

Pasz-Walczak, Grazyna ^{[3
]}

Sygut, Andrzej ^{[4
]}

Dziki, Adam ^{[4
]}

Kruk-Jeromin, Julia ^{[1
]}

机构：

[1] Med Univ Lodz, Barlicki Hosp, Dept Plast Reconstruct & Aesthet Surg, PL-90153 Lodz, Poland

[2] Med Univ Lodz, Dept Chem & Clin Biochem, PL-90647 Lodz, Poland

[3] Med Univ Lodz, Dept Pathol, PL-93509 Lodz, Poland

[4] Med Univ Lodz, Dept Gen & Colorectal Surg, PL-90647 Lodz, Poland

来源：

PATHOLOGY & ONCOLOGY RESEARCH | 2011年 / 17卷 / 04期

关键词：

Breast cancer; Angiogenesis; Cancer progression; Multiplex protein assay; ENDOTHELIAL GROWTH-FACTOR; MICROVESSEL DENSITY; TUMOR ANGIOGENESIS; TISSUE INHIBITOR; SERUM-LEVELS; EXPRESSION; CELLS; CARCINOMA; TIMP-1; METASTASIS;

D O I：

10.1007/s12253-011-9387-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Tumoural angiogenesis is essential for the growth and spread of breast cancer cells. Therefore the aim of this study was to assess the diagnostic performance of angiogenesis markers in tumours and there reflecting levels in serum of breast cancer patients. Angiogenin, Ang2, fibroblast growth factor basic, intercellular adhesion molecule (ICAM)-1, keratinocyte growth factor (KGF), platelet-derived growth factor-BB, and VEGF-A were measured using a FASTQuant angiogenic growth factor multiplex protein assay. We observed that breast cancer tumours exhibited high levels of PDGF-BB, bFGF and VEGF, and extremely high levels of TIMP-1 and Ang-2, whereas in serum we found significantly higher levels of Ang-2, PDGF-BB, bFGF, ICAM-1 and VEGF in patients with breast cancer compared to the benign breast diseases patients. Moreover, some of these angiogenesis markers evaluated in tumour and serum of breast cancer patients exhibited association with standard clinical parameters, ER status as well as MVD of tumours. Angiogenesis markers play important roles in tumour growth, invasion and metastasis. Our results suggest that analysis of angiogenesis markers in tumour and serum of breast cancer patients using multiplex protein assay can improve diagnosis and prognosis in this diseases.

引用

页码：809 / 817

页数：9

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