Influence of the reaction conditions in the N-alkylation of acridone-2-carboxylic acids

被引：0

作者：

Marill, LX ^{[1
]}

Comdom, RFP ^{[1
]}

Hermández, MM ^{[1
]}

机构：

[1] Ctr Pharmaceut Chem, Havana, Cuba

来源：

SYNTHETIC COMMUNICATIONS | 2001年 / 31卷 / 14期

关键词：

D O I：

10.1081/SCC-100104467

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis and a study about the influence of the solvent in the alkylation reaction of 2-Carboxy-6-chloro-9(10H) acridone (3b) and 2-Carboxy-6-chloro-7-nitro-9(10H) acridone (3a) was done, obtaining the N-ethyl ester derivative of the alkylated products. Using the liquid-liquid phase transfer catalysis only the N-alkylated derivative was obtained in both cases with an improved yield.

引用

页码：2159 / 2167

页数：9

共 18 条

[1] IN-VITRO ACTIVITIES OF FUROQUINOLINE AND ACRIDONE ALKALOIDS AGAINST PLASMODIUM-FALCIPARUM
BASCO, LK
MITAKU, S
SKALTSOUNIS, AL
RAVELOMANANTSOA, N
TILLEQUIN, F
KOCH, M
LEBRAS, J
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1994, 38 (05) : 1169 - 1171
[2] BERNY H, 1992, ARZNEIMITTEL-FORSCH, V42-1, P674
[3] BISIMIDAZOACRIDONES AND RELATED-COMPOUNDS - NEW ANTINEOPLASTIC AGENTS WITH HIGH SELECTIVITY AGAINST COLON TUMORS
CHOLODY, WM
HERNANDEZ, L
HASSNER, L
SCUDIERO, DA
DJURICKOVIC, DB
MICHEJDA, CJ
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1995, 38 (16) : 3043 - 3052
[4] INHIBITION OF CELL-GROWTH AND MACROMOLECULE BIOSYNTHESIS OF HUMAN PROMYELOCYTIC LEUKEMIC-CELLS BY ACRIDONE ALKALOIDS
CHOU, TC
TZENG, CC
WU, TS
WATANABE, KA
SU, TL
[J]. PHYTOTHERAPY RESEARCH, 1989, 3 (06) : 237 - 242
[5] FUJIOKA H, 1990, ARZNEIMITTELFORSCH, V40-2, P1026
[6] GALY JP, 1979, SYNTHESIS-STUTTGART, P944
[7] GAMAGE SA, 1992, ANTI-CANCER DRUG DES, V7, P403
[8] SUR LES ACIDES NITRO-5-DICHLORO-2,4-BENZOIQUES ET NITRO-3-DICHLORO-2,4-BENZOIQUES
GOLDSTEIN, H
SCHAAF, E
[J]. HELVETICA CHIMICA ACTA, 1957, 40 (05) : 1187 - 1188
[9] GORVIN J, 1976, Patent No. 3950342
[10] GORVIN J, 1981, Patent No. 4250182

← 1 2 →