Nanodrug delivery systems and cancer stem cells: From delivery carriers to treatment

被引：12
作者：
Yan, Jianqin [1 ]
Long, Xuehua [1 ]
Liang, Yan [1 ]
Li, Fashun [1 ]
Yu, Hongli [1 ]
Li, Yifei [1 ]
Li, Zhipeng [1 ]
Tian, Yu [1 ]
He, Bin [2 ,3 ]
Sun, Yong [1 ]
机构：
[1] Qingdao Univ, Sch Pharm, Dept Pharmaceut, Qingdao 266021, Peoples R China
[2] Sichuan Univ, Natl Engn Res Ctr Biomat, Chengdu 610064, Peoples R China
[3] Sichuan Univ, Sch Biomed Engn, Chengdu 610064, Peoples R China
来源：
COLLOIDS AND SURFACES B-BIOINTERFACES | 2022年 / 217卷
基金：
中国博士后科学基金;
关键词：
Cancer stem cell; Nanodrug delivery systems; Targeting strategies; Cancer therapy; BREAST-CANCER; EXTRACELLULAR VESICLES; PHOTODYNAMIC THERAPY; INITIATING CELLS; DRUG-RESISTANCE; TUMOR-GROWTH; NANOPARTICLES; TARGET; GLIOBLASTOMA; INHIBITION;
D O I：
10.1016/j.colsurfb.2022.112701
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
Cancer stem cells (CSCs) control tumor occurrence and development, chemotherapy tolerance, and cancer recurrence and metastasis due to their characteristics of high proliferation, self-renewal, multidirectional dif-ferentiation, high tumorigenicity, and multiple drug resistance. Therefore, effective elimination of CSCs is the key to improving the efficacy of cancer therapy. Due to their small size, good biocompatibility, multi-drug co -delivery, and many other advantages, nanocarriers are often used for targeted drug delivery to achieve efficient tumor therapy, and they also provide the possibility of eliminating CSCs. Therefore, this paper reviews the current carrier forms, targeting strategies, and therapeutic applications of nanodrug delivery systems (NDDS) implemented as a therapeutic option for CSCs. We also discuss the challenges and future research directions of NDDS for CSCs therapy.
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页数：14
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