Evaluation of the Daphnia magna reproduction test for detecting endocrine disruptors

被引：24

作者：

Dang, ZhiChao ^{[1
]}

Cheng, Yan ^{[2
]}

Chen, Hui-ming ^{[2
]}

Cui, Yuan ^{[2
]}

Yin, Huan-huan ^{[2
]}

Traas, Theo ^{[1
]}

Montforts, Mark ^{[1
]}

Vermeire, Theo ^{[1
]}

机构：

[1] Natl Inst Publ Hlth & Environm RIVM, NL-3720 BA Bilthoven, Netherlands

[2] Chinese Acad Inspect & Quarantine, Beijing 100123, Peoples R China

来源：

CHEMOSPHERE | 2012年 / 88卷 / 04期

关键词：

Invertebrate reproduction test; Integrated testing strategy (ITS); REACH; OECD test guidelines; Endocrine disrupting chemicals; JUVENILE-HORMONE ANALOGS; CHRONIC TOXICITY; EXPOSURE; GROWTH; INVERTEBRATES; NONYLPHENOL; SURVIVAL; FISH; PENTACHLOROPHENOL; TESTOSTERONE;

D O I：

10.1016/j.chemosphere.2012.03.012

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The Daphnia 21 d reproduction test is considered as a comprehensive and decisive test in the OECD Conceptual Framework for testing and assessment of endocrine disrupting chemicals (EDCs). However, how to interpret results of the Daphnia 21 d reproduction test for identification, risk assessment and testing strategy of EDCs remains an unsolved issue. This study analysed a total number of 135 published studies encompassing 86 known EDCs and non-EDCs with different modes of action. Our results show that the majority of effects on apical endpoints (survival, molting, growth, time to reproductive maturity, brood size, the number of broods, and the total number of offspring) do not seem to be EDC-specific. In contrast, the endpoint sex ratio is likely specific to juvenile hormones and their mimics. Variability is quantified for three most reported endpoints survival, the total number of offspring and sex ratio. Quantification of the endpoint sensitivity shows that the sensitivity of the sex ratio is lower than that of the total number of offspring. The Daphnia 21 d reproduction test gives insufficient information to conclude if a substance is an EDC or not. EDCs that are potent in assays in vitro may not be potent in the Daphnia 21 d reproduction test. We conclude that the Daphnia 21 d reproduction test is important for deriving No Observed Effect Concentrations for risk assessment but may produce false negatives in identification of EDCs when used on its own. A targeted testing strategy for selection of species, tests, and endpoints is suggested for identifying EDCs. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：514 / 523

页数：10

共 55 条

[1] Metabolic androgenization of female Daphnia magna by the xenoestrogen 4-nonylphenol [J].

Baldwin, WS ;

Graham, SE ;

Shea, D ;

LeBlanc, GA .

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 1997, 16 (09) :1905-1911

[2] Altered metabolic elimination of testosterone and associated toxicity following exposure of Daphnia magna to nonylphenol polyethoxylate [J].

Baldwin, WS ;

Graham, SE ;

Shea, D ;

LeBlanc, GA .

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 1998, 39 (02) :104-111

[3] PHYSIOLOGICAL AND BIOCHEMICAL PERTURBATIONS IN DAPHNIA-MAGNA FOLLOWING EXPOSURE TO THE MODEL ENVIRONMENTAL ESTROGEN DIETHYLSTILBESTROL [J].

BALDWIN, WS ;

MILAM, DL ;

LEBLANC, GA .

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 1995, 14 (06) :945-952

[4]

Baldwin WS, 2001, ENVIRON TOXICOL CHEM, V20, P1564, DOI [10.1897/1551-5028(2001)020<1564:IEIAIO>2.0.CO

[5]

2, 10.1002/etc.5620200721]

[6] Acute and chronic effects of testosterone and 4-hydroxyandrostenedione to the crustacean Daphnia magna [J].

Barbosa, Isabel R. ;

Nogueira, Antonio J. A. ;

Soares, Amadeu M. V. M. .

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2008, 71 (03) :757-764

[7] TOXICITY TEST PROCEDURES FOR HYALELLA-AZTECA, AND CHRONIC TOXICITY OF CADMIUM AND PENTACHLOROPHENOL TO HYALELLA-AZTECA, GAMMARUS-FASCIATUS, AND DAPHNIA-MAGNA [J].

BORGMANN, U ;

RALPH, KM ;

NORWOOD, WP .

ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY, 1989, 18 (05) :756-764

[8] Laboratory evaluation of the toxicity of perfluorooctane sulfonate (PFOS) on Selenastrum capricornutum, Chlorella vulgaris, Lemna gibba, Daphnia magna, and Daphnia pulicaria [J].

Boudreau, TM ;

Sibley, PK ;

Mabury, SA ;

Muir, DGC ;

Solomon, KR .

ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY, 2003, 44 (03) :307-313

[9] EFFECTS OF FUNCTIONALIZED FULLERENES ON BIFENTHRIN AND TRIBUFOS TOXICITY TO DAPHNIA MAGNA: SURVIVAL, REPRODUCTION, AND GROWTH RATE [J].

Brausch, Kathryn A. ;

Anderson, Todd A. ;

Smith, Philip N. ;

Maul, Jonathan D. .

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 2010, 29 (11) :2600-2606

[10] Multi-generational effects of four selected environmental oestrogens on Daphnia magna [J].

Brennan, Sarah J. ;

Brougham, Concepta A. ;

Roche, James J. ;

Fogarty, Andrew M. .

CHEMOSPHERE, 2006, 64 (01) :49-55

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