The Prevention of a High Dose of Vitamin D or Its Combination with Sulforaphane on Intestinal Inflammation and Tumorigenesis in Apc1638N Mice Fed a High-Fat Diet

被引:14
|
作者
Li, Jinchao [1 ]
Frederick, Armina-Lyn M. [1 ]
Jin, Yu [1 ,2 ]
Guo, Chi [1 ,3 ]
Xiao, Hang [4 ]
Wood, Richard J. [1 ]
Liu, Zhenhua [1 ,5 ]
机构
[1] Univ Massachusetts, Dept Nutr, Sch Publ Hlth & Hlth Sci, Amherst, MA 01002 USA
[2] China Med Univ, Shengjing Hosp, Dept Gastroenterol, Shenyang 110004, Liaoning, Peoples R China
[3] Hunan Univ, Dept Mol Med, Changsha 410006, Hunan, Peoples R China
[4] Univ Massachusetts, Dept Food Sci, Amherst, MA 01002 USA
[5] Tufts Univ, Jean Mayer USDA Human Nutr Res Ctr Aging, Boston, MA 02153 USA
关键词
colorectal cancer; inflammation; obesity; sulforaphane; vitamin D; HISTONE DEACETYLASE INHIBITORS; SERUM 25-HYDROXYVITAMIN D; NECROSIS-FACTOR-ALPHA; COLORECTAL-CANCER; INDUCED APOPTOSIS; MOUSE MODELS; TNF-ALPHA; IN-VITRO; COLON; AUTOPHAGY;
D O I
10.1002/mnfr.201800824
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
Scope The previous study shows that obesity-promoted inflammation is responsible for the activation of the intestinal tumorigenic Wnt-signaling. The present study aims to test a dietary strategy, dietary supplementation with a high dose of vitamin D (VD) or its combination with sulforaphane (SFN) to inhibit intestinal inflammation and obesity-associated tumorigenesis. Methods and results Apc(1638N) mice are randomly divided into four groups: LF, a low-fat diet (10 kcal% fat) with 200 IU VD; HF, a high-fat diet (60 kcal% fat) with 200 IU VD; HFD, a high-fat diet with 5000 IU VD; and HFDS, a high-fat diet plus 5000 IU VD and 0.23 g SFN per approximate to 4000 kcal. VD administration decreased tumor incidence and size, and the co-administration with SFN (HFDS) magnified the effects. Inflammation and Wnt-signaling are suppressed by VD. The addition of SFN decreased the activity of histone deacetylase (HDAC) and increased autophagy. Conclusion The administration of VD, at 5000 IU level, exerts an anti-inflammatory property and leads to suppressed intestinal Wnt-signaling and tumorigenesis in obese mice. The molecular function of SFN on a high dose of VD supplementation, although displayed on the inhibition of HDAC and the activation of autophagy, needs further investigation.
引用
收藏
页数:10
相关论文
共 50 条
  • [11] Lisofylline reduces inflammation in adipose tissue of mice fed a high-fat diet
    Pei, Hong
    Bevard, Melissa
    Barbera, Toni
    Nadler, Jerry L.
    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2008, 28 (06) : E67 - E67
  • [12] Brain Fatty Acid Composition and Inflammation in Mice Fed with High-Carbohydrate Diet or High-Fat Diet
    da Silva-Santi, Lorena Gimenez
    Antunes, Marina Masetto
    Mori, Marco Aurelio
    de Almeida-Souza, Camila Biesdorf
    Visentainer, Jesui Vergilio
    Carbonera, Fabiana
    Crisma, Amanda Rabello
    Masi, Laureane Nunes
    Hirabara, Sandro Massao
    Curi, Rui
    Bazotte, Roberto Barbosa
    NUTRIENTS, 2018, 10 (09)
  • [13] Liver Fatty Acid Composition and Inflammation in Mice Fed with High-Carbohydrate Diet or High-Fat Diet
    da Silva-Santi, Lorena Gimenez
    Antunes, Marina Masetto
    Caparroz-Assef, Silvana Martins
    Carbonera, Fabiana
    Masi, Laureane Nunes
    Curi, Rui
    Visentainer, Jesui Vergilio
    Bazotte, Roberto Barbosa
    NUTRIENTS, 2016, 8 (11)
  • [14] Bardoxolone methyl prevents fat deposition and inflammation in the visceral fat of mice fed a high-fat diet
    Dinh, Chi H. L.
    Szabo, Alexander
    Camer, Danielle
    Yu, Yinghua
    Wang, Hongqin
    Huang, Xu-Feng
    CHEMICO-BIOLOGICAL INTERACTIONS, 2015, 229 : 1 - 8
  • [15] ADIPOSE TISSUE INFLAMMATION OCCURS PRIOR TO LIVER INFLAMMATION IN MICE FED A HIGH-FAT DIET
    Sheedfar, F.
    Van der Heijden, R. A.
    Morrison, M. C.
    Hommelberg, P. H.
    Youssef, S.
    Gruben, N.
    De Bruin, A.
    Hofker, M. H.
    Kleemann, R.
    Koonen, D. P.
    Heeringa, P.
    JOURNAL OF HEPATOLOGY, 2015, 62 : S708 - S708
  • [16] Intestinal Dysbiosis Contributes to the Delayed Gastrointestinal Transit in High-Fat Diet Fed Mice
    Anitha, Mallappa
    Reichardt, Francois
    Tabatabavakili, Sahar
    Nezami, Behtash Ghazi
    Chassaing, Benoit
    Mwangi, Simon
    Vijay-Kumar, Matam
    Gewirtz, Andrew
    Srinivasan, Shanthi
    CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 2016, 2 (03): : 328 - 339
  • [17] Bacterial diversity in intestinal mucosa of mice fed with Dendrobium officinale and high-fat diet
    Xiaoya Li
    Xinxin Peng
    Kangxiao Guo
    Zhoujin Tan
    3 Biotech, 2021, 11
  • [18] Bacterial diversity in intestinal mucosa of mice fed with Dendrobium officinale and high-fat diet
    Li, Xiaoya
    Peng, Xinxin
    Guo, Kangxiao
    Tan, Zhoujin
    3 BIOTECH, 2021, 11 (01)
  • [19] BEHAVIORAL ALTERATIONS IN MICE FED A HIGH-FAT DIET ARE ASSOCIATED WITH INFLAMMATION IN THE HIPPOCAMPUS AND AMYGDALA
    Almeida-Suhett, Camila
    Rescott, Marissa
    Graham, Alice
    Yu, Tianzheng
    Chen, Yifan
    Deuster, Patricia
    ANNALS OF BEHAVIORAL MEDICINE, 2016, 50 : S254 - S254
  • [20] Combination of metformin and exercise alleviates osteoarthritis in ovariectomized mice fed a high-fat diet
    Li, Hetong
    Gou, Yu
    Tian, Faming
    Zhang, Ya
    Lian, Qiangqiang
    Hu, Yunpeng
    Zhang, Liu
    BONE, 2022, 157