A novel "on-off-on" fluorescent sensor for 6-thioguanine and Hg2+ based on g-C3N4 nanosheets

被引：54

作者：

Duan, Junling ^{[1
]}

Zhang, Yuanhong ^{[1
]}

Yin, Yanbin ^{[1
]}

Li, Houshen ^{[1
]}

Wang, Jun ^{[2
]}

Zhu, Lusheng ^{[2
]}

机构：

[1] Shandong Agr Univ, Coll Chem & Mat Sci, Tai An 271018, Shandong, Peoples R China

[2] Shandong Agr Univ, Coll Resources & Environm, Tai An 271018, Shandong, Peoples R China

来源：

SENSORS AND ACTUATORS B-CHEMICAL | 2018年 / 257卷

基金：

中国国家自然科学基金;

关键词：

g-C3N4; nanosheets; Fluorescence; Sensor; 6-Thioguanine; Mercury; GRAPHITIC CARBON NITRIDE; QUANTUM DOTS; AQUEOUS-SOLUTION; LYMPHOBLASTIC-LEUKEMIA; SELECTIVE DETECTION; GOLD NANOPARTICLES; GREEN SYNTHESIS; CU2+; 6-MERCAPTOPURINE; MERCURY;

D O I：

10.1016/j.snb.2017.10.071

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A facile fluorescence "on-off-on" approach for sensing 6-Thioguanine (6-TG) and Hg2+ was designed based on g-C3N4 nanosheets. It was found that in the absence of Hg2+, the addition of 6-TG to g-C3N4 nanosheets solution resulted in the fluorescence quenching of g-C3N4 nanosheets (turn off). However, in the presence of Hg2+, the quenched fluorescence of g-C3N4 nanosheets was recovered ( turn on), because the high affinity of Hg2+ and 6-TG resulted in the loss of molecular interactions between 6-TG and g-C3N4 nanosheets. The quantitative detection of 6-TG was obtained via the fluorescence quenching of g-C3N4 nanosheets with a detection limit of 65 nM. Meantime, the 6-TG-g-C3N4 nanosheets system could be used as a fluorescent "turn on" sensor for Hg2+. The detection limit for Hg2+ was 37 nM. The proposed method showed high selectivity for the detection of 6-TG and Hg2+. In addition, it was successfully applied to detect Hg2+ in real water samples. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：504 / 510

页数：7

共 52 条

[1] Selective turn-on fluorescence assay of 6-thioguanine by using harmine-modified silver nanoparticles [J].

Amjadi, Mohammad ;

Farzampour, Leila .

LUMINESCENCE, 2014, 29 (06) :689-694

[2] Facile bulk production of highly blue fluorescent graphitic carbon nitride quantum dots and their application as highly selective and sensitive sensors for the detection of mercuric and iodide ions in aqueous media [J].

Barman, Sudip ;

Sadhukhan, Mriganka .

JOURNAL OF MATERIALS CHEMISTRY, 2012, 22 (41) :21832-21837

[3] Determination of 6-thioguanine based on localized surface plasmon resonance of gold nanoparticle [J].

Bi, Ning ;

Hu, Meihua ;

Zhu, Hongyu ;

Qi, Haibo ;

Tian, Yuan ;

Zhang, Hanqi .

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 2013, 107 :24-30

[4] A VALIDATED HPLC METHOD FOR THE MONITORING OF THIOPURINE METABOLITES IN WHOLE BLOOD IN PAEDIATRIC PATIENTS WITH INFLAMMATORY BOWEL DISEASE [J].

Cangemi, G. ;

Barabino, A. ;

Barco, S. ;

Parodi, A. ;

Arrigo, S. ;

Melioli, G. .

INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY, 2012, 25 (02) :435-444

[5] Trace detection of nitro aromatic explosives by highly fluorescent g-C3N4 nanosheets [J].

Chen, Hai-Yu ;

Ruan, Lin-Wei ;

Jiang, Xia ;

Qiu, Ling-Guang .

ANALYST, 2015, 140 (02) :637-643

[6] Luminescent CdS quantum dots as selective ion probes [J].

Chen, YF ;

Rosenzweig, Z .

ANALYTICAL CHEMISTRY, 2002, 74 (19) :5132-5138

[7] Graphitic carbon nitride nanosheets: one-step, high-yield synthesis and application for Cu2+ detection [J].

Cheng, Ningyan ;

Jiang, Ping ;

Liu, Qian ;

Tian, Jingqi ;

Asiri, Abdullah M. ;

Sun, Xuping .

ANALYST, 2014, 139 (20) :5065-5068

[8] The toxicology of mercury - Current exposures and clinical manifestations [J].

Clarkson, TW ;

Magos, L ;

Myers, GJ .

NEW ENGLAND JOURNAL OF MEDICINE, 2003, 349 (18) :1731-1737

[9] Modified multiwall carbon nanotubes paste electrode as a sensor for simultaneous determination of 6-thioguanine and folic acid using ferrocenedicarboxylic acid as a mediator [J].

Ensafi, Ali A. ;

Karimi-Maleh, H. .

JOURNAL OF ELECTROANALYTICAL CHEMISTRY, 2010, 640 (1-2) :75-83

[10] Highly selective Hg2+ colorimetric sensor using green synthesized and unmodified silver nanoparticles [J].

Farhadi, Khalil ;

Forough, Mehrdad ;

Molaei, Rahim ;

Hajizadeh, Salahaddin ;

Rafipour, Aysan .

SENSORS AND ACTUATORS B-CHEMICAL, 2012, 161 (01) :880-885

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