Advances in the Synthesis of Bioactive Unnatural Amino Acids and Peptides

被引：41
作者：
Saladino, R. [1 ]
Botta, G. [1 ]
Crucianelli, M. [2 ]
机构：
[1] Univ Tuscia, Dipartimento Agrobiol & Agrochim, I-01100 Viterbo, Italy
[2] Univ Aquila, Dipartimento Chim Ingn Chim & Mat, I-67100 Laquila, Italy
来源：
MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2012年 / 12卷 / 04期
关键词：
Unnatural amino acids; peptidomimetics; biological activity; synthesis; structural preperties; SIDE-CHAIN; BETA-AMINO; STEREOSELECTIVE-SYNTHESIS; ALPHA-TRIFLUOROMETHYL; ENANTIOSELECTIVE SYNTHESIS; MECHANISTIC INSIGHT; EFFICIENT SYNTHESIS; OXIDATIVE STRESS; BUILDING-BLOCKS; RECENT PROGRESS;
D O I：
10.2174/138955712799829276
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The key role of proteins and amino acids in the structure and function of living matter has stimulated extensive studies. Modified amino acids with enhanced biological activity, proteolitic stability and bioavailability are of increasing interest in protein design and engineering as drug candidates. In the last few years, several efforts have been devoted to the synthesis of amino acids having unusual side chains and unnatural chirality, commonly referred to as "nonproteinogenic" or "unnatural" amino acids, even though some of them can be isolated from natural sources. In this review we describe recent advances in the amino acid side-chain transformations and backbone modifications by oxidative and fluorination procedures.
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页码：277 / 300
页数：24
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