Analysis of mebendazole polymorphs by Fourier transform infrared spectrometry using chemometric methods

被引：9
作者：
Bunaciu, AA
Fleschin, S
Aboul-Enein, HY
机构：
[1] King Faisal Specialist Hosp & Res Ctr, Biol & Med Res Dept MBC03, Bioanalyt & Drug Dev Lab, Riyadh 11211, Saudi Arabia
[2] Mettler Toledo AG, Analyt Expertise Dept, OF Syst, Bucharest 70644, Romania
[3] Univ Bucharest, Dept Analyt Chem, Bucharest 76229 90 92, Romania
来源：
SPECTROSCOPY LETTERS | 2001年 / 34卷 / 05期
关键词：
Fourier transform infrared spectrometry; polymorphic analysis; mebendazole drug analysis; chemometric analysis;
D O I：
10.1081/SL-100106868
中图分类号：
O433 [光谱学];
学科分类号：
0703 ; 070302 ;
摘要：
A Fourier transform infrared (FT-IR) spectrometric method diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS) was developed for the rapid, direct measurement of mebendazole in drugs. Conventional KBr-spectra and DRIFTS-spectra were compared for best determination of active substance in drug formulations. Two chemometric approaches, partial least-squares (PLS2) and principal component regression (PCR+) methods were used in data processing. The best results were obtained with the PLS2 method.
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页码：527 / 536
页数：10
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