Three year joint space narrowing predicts long term incidence of knee surgery in patients with osteoarthritis: an eight year prospective follow up study

被引:47
作者
Bruyere, O
Richy, F
Reginster, JY
机构
[1] Univ Liege, Dept Publ Hlth Epidemiol & Hlth Econ, B-4000 Cointe Ougree, Belgium
[2] Univ Liege, WHO Collaborating Ctr Publ Hlth Aspects Osteoarti, B-4000 Cointe Ougree, Belgium
关键词
D O I
10.1136/ard.2005.037309
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective: To assess the clinical relevance of mean and minimum femorotibial joint space narrowing (JSN) for predicting future osteoarthritis related surgery in patients with knee osteoarthritis. Methods: 126 subjects with primary knee osteoarthritis were followed prospectively for a mean eight years. Minimum and mean joint space width (JSW) were assessed from standard x rays at baseline and after a follow up of three years. The rate of knee osteoarthritis related surgery was recorded for the following five years. Results: After a mean follow up of eight years, 16 patients (12.7%) had received osteoarthritis related joint surgery. The areas under the curves (AUC) resulting from the receiver operating characteristic curve analyses for predicting osteoarthritis surgery were 0.73 (p = 0.006) for minimum JSN and 0.55 (p = 0.54) for mean JSN. The cut off for minimum JSN maximising sensitivity and specificity for predicting future surgery was a change of 0.7 mm or more in minimum joint space width over a period of three years. However, no meaningful differences were observed for cut off values between 0.5 and 0.8 mm The relative risk (adjusted for age, body mass index, baseline symptoms, and baseline JSW) of experiencing osteoarthritis related surgery during the eight year of follow up was 5.15 (95% confidence interval, 1.70 to 15.60) (p = 0.004) in patients with a minimum joint space narrowing of 0.7 mm or more during the first three years of the study. Conclusions: A cut off of 0.5 to 0.8 mm in minimum JSN, measured on standard x rays, reflects a clinically relevant progression in patients with knee osteoarthritis.
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页码:1727 / 1730
页数:4
相关论文
共 18 条
  • [1] Recommendations for the use of new methods to assess the efficacy of disease-modifying drugs in the treatment of osteoarthritis
    Abadie, E
    Ethgen, D
    Avouac, B
    Bouvenot, G
    Branco, J
    Bruyere, O
    Calvo, G
    Devogelaer, JP
    Dreiser, RL
    Herrero-Beaumont, G
    Kahan, A
    Kreutz, G
    Laslop, A
    Lemme, EM
    Nuki, G
    Van de Putte, L
    Vanhaelst, L
    Reginster, JY
    [J]. OSTEOARTHRITIS AND CARTILAGE, 2004, 12 (04) : 263 - 268
  • [2] Design and conduct of clinical trials in patients with osteoarthritis: Recommendations from a task force of the Osteoarthritis Research Society - Results from a workshop
    Altman, R
    Brandt, K
    Hochberg, M
    MOskowitz, R
    Bellamy, N
    Bloch, DA
    Buckwalter, J
    Dougados, M
    Ehrlich, G
    Lequesne, M
    Lohmander, S
    Murphy, WA
    RosarioJansen, T
    Schwartz, B
    Trippel, S
    [J]. OSTEOARTHRITIS AND CARTILAGE, 1996, 4 (04) : 217 - 243
  • [3] DEVELOPMENT OF CRITERIA FOR THE CLASSIFICATION AND REPORTING OF OSTEOARTHRITIS - CLASSIFICATION OF OSTEOARTHRITIS OF THE KNEE
    ALTMAN, R
    ASCH, E
    BLOCH, D
    BOLE, G
    BORENSTEIN, D
    BRANDT, K
    CHRISTY, W
    COOKE, TD
    GREENWALD, R
    HOCHBERG, M
    HOWELL, D
    KAPLAN, D
    KOOPMAN, W
    LONGLEY, S
    MANKIN, H
    MCSHANE, DJ
    MEDSGER, T
    MEENAN, R
    MIKKELSEN, W
    MOSKOWITZ, R
    MURPHY, W
    ROTHSCHILD, B
    SEGAL, M
    SOKOLOFF, L
    WOLFE, F
    [J]. ARTHRITIS AND RHEUMATISM, 1986, 29 (08): : 1039 - 1049
  • [4] Update: Treatment of osteoarthritis
    Chard, J
    Dieppe, P
    [J]. ARTHRITIS & RHEUMATISM-ARTHRITIS CARE & RESEARCH, 2002, 47 (06): : 686 - 690
  • [5] Rate of cartilage loss at two years predicts subsequent total knee arthroplasty: a prospective study
    Cicuttini, FM
    Jones, G
    Forbes, A
    Wluka, A
    [J]. ANNALS OF THE RHEUMATIC DISEASES, 2004, 63 (09) : 1124 - 1127
  • [6] Committee for Proprietary Medicinal Products, 1998, POINTS CONS CLIN INV
  • [7] DACRE JE, 1989, BRIT J RHEUMATOL, V28, P506
  • [8] Knee replacement surgery for osteoarthritis: effectiveness, practice variations, indications and possible determinants of utilization
    Dieppe, P
    Basler, HD
    Chard, J
    Croft, P
    Dixon, J
    Hurley, M
    Lohmander, S
    Raspe, H
    [J]. RHEUMATOLOGY, 1999, 38 (01) : 73 - 83
  • [9] Dougados M, 1997, REV RHUM, V64, P795
  • [10] Radiological progression of hip osteoarthritis: Definition, risk factors and correlations with clinical status
    Dougados, M
    Gueguen, A
    Nguyen, M
    Berdah, L
    Lequesne, M
    Mazieres, B
    Vignon, E
    [J]. ANNALS OF THE RHEUMATIC DISEASES, 1996, 55 (06) : 356 - 362