The assembly and disassembly of the AcrAB-TolC three-component multidrug efflux pump

被引：21

作者：

Mueller, Reinke Tobias ^{[1
]}

Pos, Klaas Martinus ^{[1
]}

机构：

[1] Goethe Univ Frankfurt, Inst Biochem, D-60438 Frankfurt, Germany

来源：

BIOLOGICAL CHEMISTRY | 2015年 / 396卷 / 9-10期

关键词：

antibiotic resistance; proton-motive force; transport; tripartite efflux pumps; ESCHERICHIA-COLI; TRANSPORTER ACRB; CRYSTAL-STRUCTURE; BINDING POCKET; SWITCH-LOOP; MECHANISM; DYNAMICS; BACTERIA; SIMULATIONS; INHIBITION;

D O I：

10.1515/hsz-2015-0150

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In Gram-negative bacteria, tripartite efflux pumps, like AcrAB-TolC from Escherichia coli, play a prominent role in the resistance against multiple antibiotics. Transport of the drugs across the outer membrane and its coupling to the electrochemical gradient is dependent on the presence of all three components. As the activity of the E. coli AcrAB-TolC efflux pump is dependent on both the concentration of substrates and the extent of the electrochemical gradient across the inner membrane, the -dynamics of tripartite pump assembly and disassembly might be crucial for effective net transport of drugs towards the outside of the cell.

引用

页码：1083 / 1089

页数：7

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